Malaria Research and Control

This study identifies residual Anopheles gambiae populations in frontier communities in Tanzania linked to nocturnal livelihood activities, suggesting potential for re-emergence despite LLIN coverage.

The paper investigates how innate immune responses to Plasmodium falciparum contribute to blood-brain barrier disruption in cerebral malaria using an in vitro model.

The paper surveys Anopheles mosquito species and insecticide resistance in refugee camps in Kenya, finding spatial variation in species composition and high pyrethroid resistance in some populations.

This study reviews P. falciparum research in Africa from 2000 to 2024, showing growth in publications and key themes, but highlighting gaps in genomic surveillance and local collaboration.

The paper shows that random search by CD8 T cells for Plasmodium parasites is efficient in liver sinusoids, challenging the need for attraction-based search.

This study shows that PfDGAT is essential for Plasmodium falciparum survival by maintaining phospholipid homeostasis, regulating sexual differentiation, ER stress, and cytoadhesion.

This study identifies PfJmjC1 as a key regulator of heterochromatin organization in Plasmodium falciparum, showing its role in genome architecture and parasite life cycle.

This study identifies a Plasmodium falciparum redox survival mechanism involving K13 that enables artemisinin-induced death in resistant strains.

This study shows that inhibiting PfCLK3 disrupts RNA-splicing in malaria parasites, affecting 1125 genes and providing a novel mechanism for a radical cure.

This study identifies PfK13 mutations as drivers of artemisinin resistance by enhancing antioxidant defenses, which can be counteracted by sulforaphane.

This study shows Apicortin is localized to the apical conoid body of Plasmodium berghei during transmission but is not essential for parasite development or transmission.

This study shows that the yellow gene in Anopheles coluzzii affects pigmentation and increases susceptibility to Plasmodium berghei through microbiota-dependent mechanisms.

This study shows that PfHP1 phase separation controls var gene silencing in P. falciparum by forming heterochromatin clusters, leading to antigenic variation.

This study evaluates the effects of Ocimum basilicum extract on parasitemia, biochemical markers, and coagulation in diabetic mice with malaria, showing significant reductions in parasitemia and organ damage.

This study investigates the role of NKG7 in CD4+ and CD8+ T cells during malaria, showing protective and cell-intrinsic functions in different infection models and human infections.

This study screens historical febrile malaria samples from Kenya to track antimalarial resistance mutations over time, finding no WHO-validated artemisin resistance mutations but high prevalence of other resistance markers.

The paper shows that HbS carriers have parasites with Pfsa+ alleles, suggesting these alleles may reduce symptomatic malaria in HbS carriers.

The paper shows that fever increases adhesion of malaria parasites and neutrophils to brain blood vessels by damaging the endothelial glycocalyx, suggesting antipyretics could reduce disease severity.

This study investigates how Anopheles gambiae detects permethrin through different sensory appendages, finding that tarsi mediate behavioral responses while antennae show neural activity, supporting chemosensory receptor involvement.

This study evaluates the impact of ivermectin concentrations on survival and fecundity of Anopheles coluzzii and Aedes aegypti, finding significant effects on An. coluzzii but not Ae. aegypti.

The paper investigates how geographical variation influences the adaptive evolution of Plasmodium falciparum mutations that counteract sickle cell trait protection.

This study compares the roles of MSP4 and MSP5 in red blood cell invasion across malaria species, showing differential importance and highlighting MSP5 as a potential vaccine target for P. knowlesi and P. vivax.

The paper determines the crystal structures of engineered monoclonal antibodies MAM01 and MS-1805 in complex with Plasmodium falciparum CSP, showing retained binding affinity and no significant conformational changes.

The paper shows that atovaquone and venturicidin A work together to kill Plasmodium falciparum by blocking two pathways that generate mitochondrial membrane potential.

This study compares markers and algorithms for distinguishing recrudescence from new infection in malaria treatment trials, finding SNP-rich markers provide the most consistent results.

This study shows that sub-lethal pyrethroid exposure in Anopheles mosquitoes reduces Plasmodium falciparum transmission by increasing reactive oxygen and nitrogen species, which activate an immune pathway and destroy ookinetes.

plasmoRUtils streamlines bioinformatics analysis for Apicomplexan parasites by integrating data retrieval, harmonization, and analysis tools within R.

This study investigates the on-target activity of plasmepsin V peptidomimetics in Plasmodium falciparum by combining chemoproteomic methods and genetic validation.

The paper develops a rapid, cost-effective nanopore sequencing protocol and bioinformatics dashboard for continental-scale genomic surveillance of Plasmodium falciparum malaria in sub-Saharan Africa.