Sperm and Testicular Function

The paper identifies within-ejaculate sperm selection in humans that favors sperm with molecular signatures opposing age-related disease.

The paper identifies PTBP1's role in regulating alternative splicing of actin regulators to control Sertoli cell actin cytoskeleton dynamics during spermatogenesis.

The paper identifies a Ca2+-dependent sperm subpopulation that regulates embryo number in mammals by reducing fertilization rates when removed.

This study shows that Tmc7 deficiency in mice causes acrosome biogenesis defects and male infertility by disrupting Golgi function and ion homeostasis.

The paper associates DEFB103 copy number variation with sperm motility, oviduct epithelium binding, and uterine gene expression, potentially affecting fertility outcomes in cattle.

This study links horn size to Sertoli cell efficiency and sperm size homogeneity in common elands during sexual development, showing horn size correlates with reproductive parameters but not sperm morphology.

The paper detects ErbB2 mutations in male germline using error-corrected sequencing, finding age-related accumulation and early mutational enrichment in young donors.

The paper examines the evolution of sex hormone-binding globulin (SHBG) gene expression in primate testes, showing that exon 1A usage is unique to Hominoids and Old World Monkeys.

This study identifies IQCH as a gene critical for male fertility, showing that its deficiency causes infertility in humans and mice through defects in sperm structure and function.

This study shows that deleting a conserved TAD boundary near Dmrtb1 and Lrp8 in mice impairs spermatogenesis but not fertility.

This study evaluates the effects of white and black truffle extracts on human sperm parameters in vitro, finding both stimulating and inhibitory effects.

The paper assesses DNA accessibility in human sperm using NicE-view, finding two sub-populations with varying accessibility linked to reproductive outcomes.

The paper shows that the MEIOC-YTHDC2-RBM46 complex destabilizes mRNAs of transcriptional repressors in mouse spermatogenic cells, enhancing their competence to initiate meiosis in response to retinoic acid.

This study uses scRNA-seq and scATAC-seq to identify stage-specific interactions between Sertoli cell subtypes and germ cells in NOA, revealing potential molecular markers for diagnostic kits.

This study identifies eccDNA in human male germline and links its abundance to chronic diseases through transcriptional activity and apoptosis signaling.

The paper shows that mating in Drosophila males increases ecdysone signaling, disrupting germline stem cell cytokinesis and causing stem cell loss over time.

The paper shows that NUP210L and BAF-L are required for nuclear integrity and microtubule organization during mouse spermatid development.

This study shows that Trim66 deficiency in male mice leads to paternal transmission of intrauterine overgrowth in offspring.

This study compares semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility, finding no overall association but highlighting Flavobacterium's potential role.

This study identifies HSF5 as a male germ cell-specific factor critical for meiotic prophase progression beyond pachytene under non-stress conditions.

This study identifies a foetal-like state 0B in human spermatogonial stem cells that maintains a suppressive transcriptomic program, contrasting with rodent models where this state is not maintained into adulthood.

This study investigates the role of the sperm hook in house mice, finding it aids in sperm attachment to the epithelium and facilitates synchronized movement during migration through the female reproductive tract.

The paper maps the molecular architecture of the Head-Tail Coupling Apparatus (HTCA) in Drosophila spermiogenesis, revealing its multi-point attachment structure involving the proximal centriole-like (PCL) structure.

The paper identifies differentially expressed miRNAs in sperm of partners of recurrent miscarriage patients and links hsa-miR-34c-5p downregulation to increased miscarriage risk via bioinformatics and RT-PCR validation.

The paper introduces HISTA, an interactive scRNA-seq reference for the human testis, and demonstrates its use in analyzing lncRNA regulation and NANOS gene function in spermatogenesis.

The paper shows that spermatogonia differentiation triggers somatic support cells to form septate junctions, essential for germ cell survival in Drosophila.

The paper analyzes the impact of puberty blockers on testicular cell states and function using single-cell RNA sequencing and clinical data from PB-treated children.

The paper identifies genotype-specific meiotic impairments in infertile men with loss-of-function variants in M1AP or ZZS genes, showing different recombination failures and reproductive outcomes.

This study shows that CRISP1 and CRISP3 in the epididymis affect sperm DNA integrity and early embryo development, beyond their role in fertilization.