Sperm and Testicular Function

This study uses advanced imaging techniques to clarify SUN5's localization and dynamics during spermiogenesis, resolving previous controversies about its structure and function.

This study identifies cyanoquinoline-based HIPK4 inhibitors with nanomolar potency and reveals their cell-type-specific effects on HIPK4 proteostasis and autophagy.

This study identifies amyloid fibrils in seminal fluid that bind and deliver RNA to sperm and the zygote during fertilization.

This study identifies fertility-predictive protein and miRNA cargo in seminal extracellular vesicles from boar AI doses and shows their functional impact on sperm physiology.

This study shows that adding seminal plasma-derived extracellular vesicles to ram semen cryopreservation improves membrane lipid organization and intracellular calcium levels, and alters sperm movement patterns.

This study identifies SMZ-1/2 as PDZ proteins that initiate MSP filament assembly and FB-MO biogenesis in C. elegans sperm by coupling kinase signaling to organelle formation.

The paper investigates the fertility of male mice with one allele loss of Prm1 and Prm2, finding infertility due to sperm damage and protamine precursor retention.

This study uses AID-mediated NANOS2 knockdown to show that sustained NANOS2 expression is essential for establishing functional spermatogonial stem cells during embryonic development.

The paper identifies conserved genes linking cognition and reproduction across five species using proteomic and transcriptomic data.

This study shows EGME exposure alters sperm small RNA profiles in rats, with dose-dependent changes in miRNAs, piRNAs, and tsRNAs, potentially affecting embryonic development.

This study investigates the relationship between seminal redox potential (ORP) and sperm quality in boars, finding that ORP correlates with antioxidant capacity, sperm concentration, pH, and mitochondrial activity during storage.

This study investigates the physical consequences of extreme sperm length in fruit flies, revealing collective material flows and active stresses that maintain functional sperm organization.

This study shows that the eutherian-specific histone H3.4 variant promotes male germ cell development and reproductive fitness through specific sequence variations.

The paper shows that somatic gonadal cells in testes break down sugars to produce lactate for germ cell survival, highlighting metabolic compartmentalization as essential for germline maintenance.

This study shows that ABHD2 activity is not required for progesterone-induced Ca2+ influx via CatSper and subsequent motility changes in human sperm.

This study uses deep learning with label-free imaging flow cytometry to automate bovine sperm morphology classification, achieving high accuracy and highlighting the need for standardized datasets.

The paper investigates functional and localization differences among orthologs of the Drosophila melanogaster essential gene gdrd, finding that some orthologs can rescue fertility while others cannot due to structural and physicochemical differences.

This study shows that SIRT7 maintains genome stability in aging mouse testes by regulating H3K36ac, preventing premature loss of spermatogonia and meiotic defects.

This paper develops a microfluidic device using surface engineering to selectively remove DNA-damaged sperm through antibody-mediated negative selection, improving sperm quality for assisted reproduction.

This study shows that TENT5C regulates Odf1 poly(A) tail length, affecting sperm morphology and fertility by controlling ODF1 protein localization.

This study shows epididymal extracellular vesicles transfer mRNAs to sperm, which then influence early embryo gene expression.

This study shows that SPRY4-ERK signaling acts as a checkpoint to restore spermatogenesis after germline stem cell damage, with its loss leading to impaired regeneration and fertility.

This study shows that glycogen metabolism in Sertoli cells supports germ cell colonization during early testis development through lactate production, highlighting a critical metabolic dependency.

This paper introduces a framework for evaluating sperm trajectory tracking in crowded microscopy videos to improve automated motility analysis.

This study shows that ARPM1 is essential for acrosome biogenesis and sperm function in mice, with defects leading to subfertility and morphological abnormalities.

This study identifies the essential role of CATSPERε extracellular domains in assembling the CatSper channel complex and modulating sperm hyperactivation and fertilization.

This study identifies how the meiotic driver Stellate in D. melanogaster impairs sperm development by delaying nuclear envelope remodeling and disrupting dense complex formation.

The paper investigates the evolution of sperm energetics in mammals by analyzing gene duplication and loss of Atp1a4, revealing its role in sodium-dependent glucose uptake and subsequent pseudogenization in three lineages.

The paper introduces the Wildlife Sperm Index (WSI), a standardized scoring system that integrates sperm quality metrics to improve gamete assessment and support assisted reproduction and biobanking in wildlife conservation.