Antibiotic Resistance in Bacteria

The paper examines the mobilome of multidrug-resistant Enterococcus faecalis from healthy piglets, identifying mobile genetic elements and their roles in antibiotic resistance and adaptation.

This study uses label-free proteomics to identify proteomic changes in K. pneumoniae exposed to colistin, revealing membrane remodelling and metabolic shifts as key adaptive responses.

This study analyzes 441 ExPEC strains from swine lungs in China, revealing high antibiotic resistance gene diversity and horizontal transfer potential, with implications for AMR surveillance.

This study compares the genomic adaptations of Acinetobacter baumannii strains in Mexico before and during the COVID-19 period using whole-genome sequencing, revealing increased resistance genes, virulence factors, and mobilome elements.

This study identifies carbapenemase-producing E. coli in swine wastewater in Shandong, China, highlighting their multidrug resistance and genetic diversity.

This study shows that gene amplification increases antibiotic resistance but also imposes growth costs and increases susceptibility to high antibiotic concentrations.

This study identifies a novel hypervirulent extensively drug-resistant ST383 K. pneumoniae lineage in Lebanon carrying ICEKp5 and multiple resistance genes.

This study evaluates the in vitro activity of APC148 combined with carbapenems against MBL-producing Enterobacterales isolates, showing high susceptibility rates.

The paper identifies a novel mechanism of ceftolozane-tazobactam resistance in Pseudomonas aeruginosa mediated by an L2 β-lactamase gene, independent of its canonical regulator.

This paper develops a multimodal AI model for rapid AMR prediction using genomic and cellular data, identifying key genomic motifs and phenotypic features associated with antimicrobial resistance.

The paper shows that destabilizing the integron synaptic complex with peptides reduces bacterial adaptation to antibiotics without antimicrobial activity.

This study measures the fitness effects of 136 antimicrobial resistance genes in changing environments and finds that oxygen availability modulates their cost.

This study evaluates APC24-7, a novel β-lactamase inhibitor, showing it restores meropenem activity against CRE in vitro and in vivo.

This study tracks the in vivo evolution of an antibiotic-resistant E. coli strain in an infant gut, showing a reduction in IS26-mediated resistance gene arrays without fitness or susceptibility changes.

The paper analyzes antimicrobial resistance gene mobility across 8000 bacterial species, finding that certain resistance mechanisms are more associated with mobile elements than others.

This study uses whole-genome sequencing to characterize a multidrug-resistant Klebsiella pneumoniae outbreak in a Gambian hospital, identifying the outbreak strain and its environmental sources.

This paper develops a workflow for detecting carbapenemase-producing Klebsiella pneumoniae in wastewater using wet-lab methods and genomics, finding high prevalence and specific genetic markers.

This paper reveals that Thanatin inhibits NDM-1 by preserving its zinc center while restricting dynamics, contrasting with zinc-displacement models and showing reduced bacterial viability.

The paper analyzes RND efflux pump genes in plant-associated bacteria, finding increased diversity and horizontal gene transfer contributions to adaptation.

The paper uses whole-genome sequencing to study ESBL-Ec transmission networks in rural Malawi, finding high colonization rates and multi-household spread.

The paper identifies novel β-lactamase genes from environmental Pseudomonas spp. isolates, showing their resistance properties and potential clinical relevance.

BRIDGE improves antimicrobial resistance gene prediction by integrating gene neighbourhood and protein-protein interaction data, achieving 97% classification accuracy.

The paper examines how ecological contexts influence the duplication and mobilization of antibiotic and metal resistance genes in bacteria across different environments.

This study benchmarks five ARG detection tools on simulated metagenomic datasets, showing coverage and community complexity impact accuracy, with ARGprofiler leading in F1-score and computational efficiency.

This study shows that ivermectin and moxidectin exposure leads to genomic and transcriptomic changes in bacteria, including ribosome modulation and resistance gene adjustments.

This study compares cefiderocol susceptibility testing methods against genomic resistance determinants in blaNDM-producing Enterobacterales, finding discrepancies between EUCAST and CLSI breakpoints and poor method agreement.

This study uses protein language models and machine learning to analyze antimicrobial resistance genes in African metagenomes, revealing geographic variation and key sequence features distinguishing ARGs from non-ARGs.

This study measures zeta potential in E. coli to assess colistin susceptibility and uncover resistance mechanisms by linking surface charge changes to antibiotic resistance.

The paper identifies a high-risk Klebsiella pneumoniae clone with a hybrid virulence-resistance plasmid that spreads during the Ukraine conflict and is vulnerable to lytic phages.