Antibiotic Resistance in Bacteria

The paper benchmarks 44 tools for plasmidome reconstruction from short-read assemblies in Klebsiella pneumoniae, finding PlaScope and MOB-suite as top performers.

The paper investigates the relationship between insertion sequences (IS) and metabolic capacity in four Klebsiella pneumoniae sub-lineages, finding higher IS loads correlate with reduced metabolic gene numbers and substrate utilisation.

This study shows that overexpression of the AcrAB2NodT efflux pump in Caulobacter vibrioides confers antibiotic resistance but also causes metal sensitivity due to energetic costs.

This study profiles the resistome, virulome, and mobilome in wild birds' gut microbiota, identifying antibiotic resistance genes and their potential for horizontal transfer.

This study constructs a comprehensive mutant library of TEM-1 beta-lactamase and shows that higher-order epistasis drives unpredictable evolution of antibiotic resistance to novel substrates.

This paper uses machine learning to predict antimicrobial resistance (AMR) across ESKAPE pathogens by analyzing genomic data and identifying molecular features associated with drug resistance.

This study identifies DcaP-family porins as essential for carboxylic acid utilization and infection in A. baumannii, showing functional redundancy and validating their potential as therapeutic targets.

The study analyzes the gut resistome of the Wayampi, revealing similar antibiotic resistance gene richness to Europeans but higher metal resistance gene diversity, highlighting shared and distinct resistance patterns.

This study shows that the ponAL421P mutation in PBP1 increases penicillin MIC above the clinical breakpoint and persists in N. gonorrhoeae despite penicillin's removal from treatment guidelines.

This study analyzes A. baumannii isolates from the Orang Asli community in Malaysia, revealing genetic diversity, virulence factors, and antibiotic resistance genes similar to clinical isolates.

The paper investigates eco-evolutionary feedbacks between restriction-modification systems and antimicrobial resistance gene acquisition using modeling and genome analysis.

This study analyzes mobile genetic elements in Acinetobacter isolates to understand how they facilitate antimicrobial resistance gene dissemination across different environments.

The paper introduces a knowledge graph-based framework to detect horizontal gene transfer events contributing to antimicrobial resistance, achieving high accuracy in predictions and identifying key dissemination hubs.

The paper evaluates the presence of Acinetobacter-associated class D carbapenemase genes in Enterobacterales isolates in the U.S. and finds only one case of blaOXA-23-like gene in Klebsiella pneumoniae.

This study compares heavy metal resistance and antibiotic resistance in ESBL-producing and non-ESBL-producing E. coli using MIC testing, PCR, and whole genome sequencing.

This study identifies cefiderocol resistance genes in environmental samples using functional metagenomics, revealing beta-lactamases and mobile genetic elements.

This study identifies two survival strategies in conjugative plasmids that correlate with their host range and antibiotic resistance gene dissemination.

This study sequenced A. baumannii ST19 genomes and found a loss of the T6SS locus, replaced by antibiotic resistance transposons, potentially enhancing horizontal gene transfer and population-level competitiveness.

This study identifies ENOblock, an anticancer drug, as a novel antibiotic targeting Acinetobacter baumannii enolase, showing synergy with colistin and efficacy in vivo.

This study identifies a pbpB1 mutation causing β-lactam resistance in Listeria monocytogenes isolates and shows its selection during antibiotic treatment.

This study investigates the association between OXA-1 and TEM-1 genes and piperacillin/tazobactam resistance in ESBL-producing E. coli and K. pneumoniae across three U.S. military hospitals.

The paper analyzes defense systems in multidrug-resistant Klebsiella pneumoniae strains from Ghanaian hospitals, identifying CRISPR-Cas, restriction-modification, and toxin-antitoxin systems.

This study shows CRICON reduces ESBL prevalence in bacterial communities, but ESBL persistence depends on initial community composition and plasmid escape into competitive hosts.

This study shows that chromosomal mutations in Escherichia coli enhance resistance to carbapenems when combined with plasmid-encoded OXA-48, despite not compensating for plasmid fitness costs.

This study tracks changes in gut plasmid populations and antibiotic resistance during and after antibiotic therapy in a single patient with ESBL-carrying E. coli.

This study identifies 57 compounds, including three non-antibiotics, that disrupt Gram-negative bacterial envelopes using a LacZ/CPRG reporter assay, with alexidine showing the strongest activity.

This paper uses minimal machine learning models to predict antibiotic resistance in Klebsiella pneumoniae and identifies gaps in existing AMR databases for novel marker discovery.

This study analyzes AMR gene distribution and population structure of E. coli from humans, livestock, and the environment using WGS data to show widespread gene sharing and cross-species transmission.

The paper identifies ESBL-producing Enterobacterales on vegetable plants in Madagascar, showing genetic links to human, animal, and environmental strains.

This paper identifies a new hypervirulent Klebsiella pneumoniae ST617 isolate with ESBL+ and strong biofilm-forming ability, highlighting its virulence and potential for clinical spread.