Mosquito-borne diseases and control

This study identifies metabolic reprogramming of sulfur recycling via MTA and Mat2a as a key driver of CHIKV infection and highlights potential therapeutic targets.

This study characterizes mosquito diversity and arbovirus circulation in Taï National Park, western Cote d'Ivoire, identifying key species and virus hotspots.

The paper investigates how arboviruses like chikungunya virus maintain persistent infections in mosquito cells through translational repression of viral RNA without affecting host cell fitness.

This study adjusts laboratory methods to better manipulate field-derived Aedes aegypti mosquitoes, improving blood feeding and fertilization monitoring techniques.

This study analyzes pooled Ct values from mosquito surveillance to estimate infectious mosquito prevalence, showing that Ct values reflect biologically meaningful variation and can improve transmission risk estimates.

This study examines how heatwaves affect different developmental stages of Aedes albopictus, revealing stage-specific impacts on survival, development, and microbiota.

This study examines the B cell receptor repertoire and antibody responses after 17DD-YF vaccine boosting, finding a transient antibody response with limited neutralization capacity and rapid clonal expansion of IgA and IgG isotypes.

This paper identifies Emetine dihydrochloride as a potent antiviral against Chikungunya virus, showing reduced viremia and absence of joint swelling in mice.

This study identifies mRNA 3'-end processing protein complexes as interactors of DENV NS3 and shows their presence, not enzymatic activity, is critical for DENV replication.

The paper identifies orally bioavailable inhibitors of the Zika virus NS2B-NS3 protease that show antiviral activity in vitro and reduce viral RNA load in a murine infection model.

This paper uses disaggregation regression to predict dengue incidence in Africa from aggregated data, showing better alignment with reported cases than environmental suitability models.

This study shows that parental exposure to wet and dry conditions affects egg viability, thermotolerance, and nutrient composition in Aedes aegypti.

This study examines how prolonged dehydration stress affects Mayaro virus infection and vector competence in Aedes aegypti mosquitoes, finding that dehydration alters viral dissemination dynamics.

This study identifies key factors regulating JEV replication differences in human and porcine macrophages through multi-omics analysis and functional validation.

The paper shows that larval environment affects adult mosquito traits and disease transmission through molecular and phenotypic changes.

The paper maps YFV interactomes in human and mosquito cells, identifies RBBP6 as a restriction factor, and reveals divergent host interaction strategies among flaviviruses.

This study identifies cholesteryl ester-enriched lipid droplets as critical host components required for flavivirus infection and shows their role in viral morphogenesis.

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

This study shows 25-hydroxycholesterol inhibits dengue virus by disrupting membrane fusion, modulating cholesterol metabolism, and enhancing innate immunity.

This study uses third-generation sequencing to analyze blood meal sources of Aedes aegypti in Houston and Phoenix, finding frequent multiple host feeding and a broad host range beyond humans.

This study shows that arboviruses reduce salivation in Aedes aegypti mosquitoes by disrupting salivary gland organization, potentially enhancing virus transmission.

The paper tests if UK Culex pipiens molestus mosquitoes can transmit Oropouche virus, finding no evidence of infection in tested individuals.

This study investigates USUV infections in Swiss wild birds, identifying common blackbirds as primary hosts and linking environmental factors and genetic diversity to the 2018 outbreak.

This study shows that pre-existing YFV-17D immunity reduces DENV-2 infection severity in mice through T cell cross-protection, not antibodies.

This study uses rhesus macaques to model MAYV infection and transmission to Aedes aegypti mosquitoes, finding short viremia, low transmission rates, and limited mosquito infectivity.

This study detects the invasive mosquito Aedes vittatus in Jamaica and identifies its genetic origins through mitochondrial genome analysis.

This study identifies tissue-specific antiviral mechanisms in mosquitoes, showing that enhancing Dicer2 in salivary glands reduces arbovirus transmission.

This study reviews 178 studies on mosquito range shifts, finding most expansions linked to human activities rather than climate change.

This study shows SIRT2 reduces JEV infection in mice by inhibiting NF-κB and enhancing autophagy, improving survival and reducing viral load.