Cell death mechanisms and regulation

This study uses live imaging to show that SARM1 activation leads to a sequence of cellular events starting with ATP loss and ending in axonal self-destruction.

This study identifies a non-apoptotic role for Drice, a caspase, in regulating cytoskeleton organization and morphology of Drosophila Malpighian tubules, impacting excretory function.

The paper identifies RHG gene family homologs in multiple insect species, revealing deep conservation and evolutionary divergence within the family.

The paper shows necrosis-induced apoptosis promotes regeneration in Drosophila wing imaginal discs by activating JNK signaling at the wound edge and triggering distant apoptosis.

This paper introduces GEDI, a fluorescent biosensor that detects early irreversible commitment to cell death in neurons, enabling real-time and high-throughput analysis of neurodegeneration.

This study expresses human Caspase-1 and Caspase-8 in yeast, comparing their effects on cell death and organelle damage, finding Caspase-8 more aggressive and identifying Bni1 as a substrate.

The paper shows that local ERK feedbacks prevent concomitant cell elimination in epithelia, maintaining sealing during high cell death rates.

The paper shows TNF shifts cells from slow, accurate to fast, error-prone apoptosis decisions, which limits HSV-1 spread.

This study shows that in Caspase-8 deficient neuroblastoma cells, TLR3 activation leads to lysosomal cell death instead of apoptosis.

This study shows that MCL-1 is essential for the survival of early erythroid progenitors, while BCL-xL takes over in later stages of erythropoiesis.

This study presents a mathematical model of how BAX and SMAC regulate the bistable properties of the apoptotic caspase system, validated by experimental and computational evidence.

This study shows that Dronc, a Drosophila caspase, regulates enteroblast quiescence non-apoptotically through Notch and Insulin-TOR pathways, providing insights into caspase-related intestinal malignancies.

The paper identifies PIG-1 MELK's role in promoting apoptosis by partitioning CES-1 Snail during neuroblast division in C. elegans.

This study shows that separase and caspases, though specialized in cell division and apoptosis, can partially substitute for each other in C. elegans, suggesting evolutionary co-option of cellular components.

This study shows that RIP1 kinase inhibition reduces pathological angiogenesis by modulating macrophage polarization in mouse models.

The paper shows that egl-1, a BH3-only gene in C. elegans, is transcriptionally regulated by neuronal activity and kinases in adult sensory neurons without inducing apoptosis.

This study shows that Eiger in Drosophila can induce both apoptosis and non-apoptotic necrosis, with necrosis requiring JNK and caspase activity independent of apoptosis.

This study shows that inhibiting HtrA2 reduces colitis by preventing necroptosis in intestinal epithelial cells in DSS-induced colitis models.

This study identifies four FDA-approved drugs as novel non-peptide allosteric inhibitors of caspase-3/7 through virtual screening and experimental validation.