Parathyroid Disorders and Treatments

Dietary phosphorus restriction enables multigenerational breeding of α-Klotho-deficient rats

This study shows that dietary phosphorus restriction allows for the multigenerational breeding of α-Klotho-deficient rats, improving survival and reproductive outcomes.

FGFR1-phosphate sensing and crystal-induced gasdermin D signaling in neutrophils drive vascular calcification in CKD

This study identifies FGFR1-phosphate sensing and GSDMD-mediated NETs as drivers of vascular calcification in CKD, offering therapeutic targets.

NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20highCHGAhigh oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidism

This study identifies an NFIC-driven endo-lysosomal pathway causing CaSR downregulation in SHPT and shows HCQ can reverse this process.

Cell-based calcification assays - magnesium overrules calcium phosphate saturation in overall outcome

The paper investigates how magnesium affects calcification in soft tissues by stabilizing protein-mineral particles, showing magnesium can both inhibit and promote calcification depending on its concentration.

TGF-β signaling regulates the response of the skeleton to phosphate

This study identifies TGF-β signaling as a regulator of phosphate homeostasis by enhancing Pi uptake in osteogenic cells and influencing FGF23 levels.

Disruption of the FGFR1-FGF23-Phosphate Axis and Targeted Therapy in a Murine Model of Osteoglophonic Dysplasia

This study creates a murine model of Osteoglophonic Dysplasia by introducing a gain-of-function FGFR1 variant, revealing pathogenic mechanisms and demonstrating therapeutic potential with infigratinib.

The role of Platelet-derived growth factor (PDGF) in uremic vascular calcification.

This study investigates the role of PDGFR-{beta} in uremic vascular calcification using ex vivo and in vivo models, showing that PDGFR-{beta} activation promotes calcification and VSMC phenotypic switching.

A Novel FNDC1-NAMPT-NAD axis is Implicated in Small and Large-vessel Arterial Disease and Drives Vascular Calcification

This study identifies FNDC1 as a key regulator of vascular calcification through the FNDC1-NAMPT-NAD axis, showing its role in both microvascular and macrovascular diseases and its potential as a therapeutic target.

Phosphorus Bioaccessibility of Processed Soy and Pulse Protein Products Measured by In Vitro Simulation of Human Digestion

This study compares phosphorus bioaccessibility of processed soy and pulse protein products with animal protein products using in vitro digestion, finding some plant-based alternatives have lower bioaccessible phosphorus.

Niacin protects against vascular calcification via enhanced SIRT1 and SIRT6 signaling and promoted VSMC autophagy

This study shows niacin reduces vascular calcification by enhancing SIRT1 and SIRT6 signaling and promoting VSMC autophagy.

The Effect of Intracerebroventricular Fibroblast Growth Factor 23 on gene expression in the Rats' Hypothalamus

This study examines the effects of intracerebroventricular FGF23 injection on gene expression in rat hypothalamic regions, finding increased ER stress markers without affecting receptor complex or metabolic gene expression.

Ap2s1 mutation in mice causes familial hypocalciuric hypercalcemia type 3

This study creates a mouse model with an AP2S1 mutation causing FHH3, showing hypercalcemia and demonstrating cinacalcet's effect on calcium levels.

Post-Transcriptional Bone Morphogenetic Protein 2 (BMP2) Gene Regulation in Aorta

This study investigates the role of an ultra-conserved sequence in Bmp2 mRNA regulation, showing sex- and disease-specific effects on BMP signaling and calcification in mouse aortas.