Parathyroid Disorders and Treatments

Dietary phosphorus restriction enables multigenerational breeding of α-Klotho-deficient rats

This study shows that dietary phosphorus restriction allows for the multigenerational breeding of α-Klotho-deficient rats, improving survival and reproductive outcomes.

TMEM174 Deficiency Reduces Longevity by Promoting Phosphate-Driven Vascular Calcification

This study shows TMEM174 deficiency shortens lifespan by promoting phosphate-driven vascular calcification through its role in NPT2A regulation.

High-salt diet modulates endocrine regulation between cortisol and FGF23

This study shows high-salt diets increase urinary cortisol and decrease plasma FGF23, revealing a novel endocrine interaction with implications for bone, kidney, and cardiovascular health.

Accelerated osteocytic citrate production in chronic kidney disease is associated with protection of the kidney

This study shows that accelerated citrate production by osteocytes in CKD mice protects kidney function, suggesting citrate handling as a therapeutic target.

PTH-Induced Behavioral and Metabolic Alterations in Mouse Models of Hyperparathyroidism

This study examines the behavioral and metabolic effects of PTH in mouse models of hyperparathyroidism, finding sex-specific behavioral changes and metabolic alterations.

FGFR1-phosphate sensing and crystal-induced gasdermin D signaling in neutrophils drive vascular calcification in CKD

This study identifies FGFR1-phosphate sensing and GSDMD-mediated NETs as drivers of vascular calcification in CKD, offering therapeutic targets.

NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20highCHGAhigh oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidism

This study identifies an NFIC-driven endo-lysosomal pathway causing CaSR downregulation in SHPT and shows HCQ can reverse this process.

The renal response to FGF23 shifts from phosphaturia towards inflammation in kidney disease

This study shows that excess FGF23 drives inflammation in kidney disease models and human data, suggesting it as a therapeutic target.

Unraveling the Mechanistic Links Between Blood Pressure Regulation and Calcium-Magnesium Homeostasis: Insights into Hypertension, Hyperparathyroidism, and Mineral Disorders

This study develops a computational model of blood pressure regulation and calcium-magnesium homeostasis in rats, showing how disruptions in these systems affect each other and contribute to hypertension and hyperparathyroidism.

The Impact of a Western Diet High in Phosphate on the CKD-MBD in an Alport Syndrome Model

This study shows a Western high-phosphate diet worsens CKD-MBD features in Alport Syndrome mice, increasing PTH and FGF23 while reducing klotho, but does not induce vascular calcification.

Cell-based calcification assays - magnesium overrules calcium phosphate saturation in overall outcome

The paper investigates how magnesium affects calcification in soft tissues by stabilizing protein-mineral particles, showing magnesium can both inhibit and promote calcification depending on its concentration.

TGF-β signaling regulates the response of the skeleton to phosphate

This study identifies TGF-β signaling as a regulator of phosphate homeostasis by enhancing Pi uptake in osteogenic cells and influencing FGF23 levels.

Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in Chronic Kidney Disorder induced Vascular Calcification.

This study shows targeted chelation therapy with EDTA-NP reduces senescent cells and NLRP3 expression in calcified aortas of CKD models.

Disruption of the FGFR1-FGF23-Phosphate Axis and Targeted Therapy in a Murine Model of Osteoglophonic Dysplasia

This study creates a murine model of Osteoglophonic Dysplasia by introducing a gain-of-function FGFR1 variant, revealing pathogenic mechanisms and demonstrating therapeutic potential with infigratinib.

Genetic ablation of Pth4 disrupts calcium-phosphate balance, bone development, and kidney transcriptome in teleosts

This study shows that knocking out Pth4 in zebrafish causes calcium-phosphate imbalance, skeletal issues, and changes in kidney gene expression.

The role of Platelet-derived growth factor (PDGF) in uremic vascular calcification.

This study investigates the role of PDGFR-{beta} in uremic vascular calcification using ex vivo and in vivo models, showing that PDGFR-{beta} activation promotes calcification and VSMC phenotypic switching.

A Novel FNDC1-NAMPT-NAD axis is Implicated in Small and Large-vessel Arterial Disease and Drives Vascular Calcification

This study identifies FNDC1 as a key regulator of vascular calcification through the FNDC1-NAMPT-NAD axis, showing its role in both microvascular and macrovascular diseases and its potential as a therapeutic target.

Bidirectional Upregulation of Klotho by Triiodothyronine and Baicalein: Mitigating Chronic Kidney Disease and Associated Complications in Aged BALB/c Mice

This study shows that combining T3 and baicalein increases Klotho levels in CKD mice, reducing fibrosis and complications like cardiovascular issues and dyslipidemia.

Phosphorus Bioaccessibility of Processed Soy and Pulse Protein Products Measured by In Vitro Simulation of Human Digestion

This study compares phosphorus bioaccessibility of processed soy and pulse protein products with animal protein products using in vitro digestion, finding some plant-based alternatives have lower bioaccessible phosphorus.

Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder

This study identifies mitochondrial dysfunction and impaired mitophagy in CKD-MBD as contributors to renal osteodystrophy, showing reversible effects with rapamycin treatment.

Niacin protects against vascular calcification via enhanced SIRT1 and SIRT6 signaling and promoted VSMC autophagy

This study shows niacin reduces vascular calcification by enhancing SIRT1 and SIRT6 signaling and promoting VSMC autophagy.

In vivo contribution of Cyp24a1 promoter vitamin D response elements

This study uses CRISPR to mutate vitamin D response elements in the Cyp24a1 gene in mice to investigate their role in gene regulation by 1,25(OH)2D3, FGF23, and PTH.

The essential roles of Dicer-mediated mTORC1 signaling in parathyroid gland integrity and function: Insights from genetic mouse models and clinical data.

This study investigates the role of Dicer-mediated mTORC1 signaling in parathyroid function using genetic mouse models and clinical data, showing its critical role in maintaining gland integrity and response to CKD.

Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory Targets

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

The Nrf2/Id2 Axis in Vascular Smooth Muscle Cells: Novel Insights into the Interplay between Vascular Calcification and Aging

This study investigates the role of NRF2 in vascular calcification and aging, finding that NRF2 dysfunction contributes to vascular smooth muscle cell senescence and calcification, with ID2 as a downstream regulator.

Bidirectional Control of Parathyroid Hormone and Bone Mass by Subfornical Organ

This study identifies the subfornical organ (SFO) and paraventricular nucleus (PVN) as central neural regulators of parathyroid hormone (PTH) and bone mass through distinct neuronal subtypes and their interactions.

The Effect of Intracerebroventricular Fibroblast Growth Factor 23 on gene expression in the Rats' Hypothalamus

This study examines the effects of intracerebroventricular FGF23 injection on gene expression in rat hypothalamic regions, finding increased ER stress markers without affecting receptor complex or metabolic gene expression.

Kidney failure alters parathyroid Pin1 phosphorylation and parathyroid hormone mRNA binding proteins leading to secondary hyperparathyroidism

The paper identifies a pathway where kidney failure induces parathyroid Pin1 phosphorylation, disrupting KSRP activity and increasing PTH mRNA stability, leading to secondary hyperparathyroidism.

Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy

This study shows that increased PHOSPHO1 expression in renal osteodystrophy contributes to increased cortical bone mineral density but decreased trabecular bone density.

MicroRNA Profiles in Calcified and Healthy Aorta Differ: Therapeutic Impact of miR-145 and miR-378

This study identifies miR-145 and miR-378 as miRNAs that reduce aortic calcification in Klotho mice by repressing BMP signaling.