Bacterial biofilms and quorum sensing

This study evaluates the efficacy of tetrasodium EDTA against P. aeruginosa biofilms in different infection models, finding it effective in chronic wound and CF lung infections but not in endotracheal tube colonization.

This study identifies CdgR as a c-di-GMP receptor in Synechocystis that regulates type IV pilus-dependent functions through interactions with transcription factors SyCRP1 and SyCRP2.

This study identifies the gacSA two-component system as a sensor integrating physical and chemical cues to promote root attachment in Pseudomonas protegens Pf-5.

This study shows that E. coli's L-fucose utilization pathway enhances biofilm formation and antibiotic tolerance in polymicrobial urinary catheter communities involving E. coli, P. mirabilis, and E. faecalis.

This study identifies copper as a key mediator in mutualistic interactions between Candida albicans and Staphylococcus aureus biofilms, showing non-reciprocal copper handling and therapeutic potential via copper nanoparticles.

This study investigates how the composition and interaction of curli fibers and pEtN-cellulose in E. coli biofilms influence their mechanical properties and structure.

This study identifies metabolic cross-talk between Enterococcus faecalis and Klebsiella pneumoniae that promotes their persistence in catheter-associated urinary tract infections.

This study shows that wrinkles in biofilms arise from matrix complementarity and mechanical discontinuity between bacterial strains.

This paper investigates how cannibalism in Bacillus subtilis biofilms affects structure and composition by analyzing toxin production and spatial distribution.

This study shows nitric oxide modifies secreted metabolites' activity, reducing their antibiotic effects and causing toxicity to the producing bacteria.

This study shows low molecular weight mucins in muco-obstructive airway diseases suppress Staphylococcus aureus growth and biofilm formation, while high molecular weight mucins do not, suggesting species-specific interactions.

The paper introduces a dual-color bacterial reporter system, pCG-VmS, for tracking gene and protein expression in Pseudomonas aeruginosa, revealing two distinct T3SS populations.

This study shows that Pseudomonas aeruginosa becomes more tolerant to antibiotics when grown in confined spaces, due to mechanical stress-induced changes in efflux and membrane remodeling.

The paper uses single-cell techniques to study agr quorum sensing dynamics in Staphylococcus aureus, revealing differences in AIP sensitivity and community interaction patterns across agr-types.

This study shows that Mycobacterium abscessus enhances Pseudomonas aeruginosa biofilm formation and antibiotic tolerance in co-culture, potentially contributing to treatment challenges in cystic fibrosis patients.

This study introduces LFAB, a label-free microscopy method for high-throughput biofilm analysis, and identifies key genes regulating biofilm formation in Streptococcus pneumoniae.

The paper identifies a double-negative feedback loop between LuxT and VqmR in V. cholerae that regulates quorum-sensing genes and biofilm formation.

This study shows that 3-oxo-C12HSL from Pseudomonas aeruginosa induces apoptosis in HNSCC cells via T2R14 and mitochondrial calcium uniporter.

This study shows that Enterococcus faecalis increases antibiotic resistance in Pseudomonas aeruginosa within iron-limited biofilms by inducing specific transcriptional changes.

This study designs and evaluates new inhibitors of PqsE, an enzyme in P. aeruginosa, to disrupt its interaction with RhlR and reduce virulence.

This study identifies dispersal-specific transcriptional biomarkers in Pseudomonas aeruginosa biofilms by analyzing gene expression across attachment, maturation, and dispersal stages.

This study evolves K. pneumoniae biofilms in vitro to identify adaptive changes linked to infection, finding convergent mutations affecting capsule, fimbriae, and c-di-GMP pathways.

This study identifies key residues in RhlR that determine ligand specificity and shows how ligand-driven gene regulation affects phenazine gene expression in Pseudomonas aeruginosa.

The paper shows how matrix chemistry in bacterial biofilms affects metabolism and fitness by modulating pyocyanin retention and electron transfer efficiency.

The paper develops FRET-based c-di-GMP biosensors and applies them with FRET-To-Sort to map regulatory networks controlling c-di-GMP levels in E. coli.

This paper identifies AmrZ as a global regulator in Azotobacter vinelandii that links alginate production to c-di-GMP homeostasis by directly activating algD and specific DGCs, while reducing motility.

This study quantifies the physical properties and phenotypes of S. epidermidis biofilm-detached cell clusters after matrix-targeted disruption, revealing differences in cluster morphology and abundance across disruption methods and strains.