Spinal Cord Injury Research

This study uses computer simulations to investigate whether gait training in spinalized rats leads to stable spinal circuitry recovery, finding that both stabilizing and destabilizing learning strategies result in functional recovery but not necessarily stable circuitry.

This study develops a hydrogel scaffold with surface chemistry that promotes axon outgrowth and hindlimb recovery in spinal cord injury models.

This study investigates whether high-frequency transcutaneous spinal cord stimulation (tSCS) is more comfortable than conventional tSCS at therapeutic amplitudes, finding no significant difference in discomfort ratings.

This study shows that repeated cervical epidural stimulation in healthy rats increases spinal and cortical excitability, suggesting SEMR data should be interpreted cautiously in longitudinal studies with multiple testing sessions.

This study identifies 10-20 Hz closed-loop electrical stimulation as critical for structural and functional reconstruction of spinal sensorimotor circuits after SCI.

The paper investigates how unilateral brain injury affects hindlimb asymmetry in rats with spinal cord transections, finding that humoral signals, not the sympathetic system, mediate these effects.

This study develops a noninvasive nanodrug delivery system for spinal cord injury that targets both ROS scavenging and neuronal excitability, leading to significant functional recovery in rats.

This study uses spatial transcriptomics to map gene expression and intercellular interactions in glial scars after spinal cord injury, revealing spatial heterogeneity and lineage trajectories.

This paper introduces a non-invasive in vivo imaging system to monitor neural graft activity after spinal cord injury and shows graft integration with host behavior.

This study shows that cervical spinal cord injury in rats leads to acute lung injury and metabolic dysfunction, establishing a new animal model for studying this relationship.

This study transplants human induced pluripotent cell-derived deep cortical neurons into a rat spinal cord injury model, showing regeneration and improved sensorimotor function.

This study compares the functional properties of regenerated synapses below and above spinal cord lesion sites in lampreys to those in unlesioned animals, finding differences in synaptic vesicle numbers and release probability.

This study shows that spike-triggered intraspinal microstimulation improves motor recovery in rats with spinal cord injury, as measured by BBB scores and Horizontal Ladder task performance.

The paper profiles single nucleus RNA-seq data from spinal cord tissue after injury to identify repair-related cellular mechanisms and potential therapeutic targets.

This study shows that locomotor recovery after thoracic contusive spinal cord injury in mice is not affected by the time of day the injury occurs.

This study evaluates the therapeutic effects of AAV-NT3 injection in a rat model of cervical spinal cord injury, showing modest improvements in forelimb function but not normalization of hyperreflexia.

This paper introduces a new cryoapplication model for spinal cord injury in rats, producing consistent glial scarring with minimal invasiveness and low interanimal variability.

This study shows that a cell-containing biomaterial scaffold promotes axon regeneration and spinal circuit reorganization, enhancing motor function recovery when combined with epidural electrical stimulation after spinal transection.

This study shows that unilateral brain injury in rats causes motor asymmetry and gene expression changes in the spinal cord, mediated by neurohormonal signaling from the injured brain.

The paper identifies Yap-Ctgf signaling as a driver of glial bridging and spinal cord regeneration in zebrafish through EMT activation in ependymal progenitors.

This study uses bioluminescent-optogenetics to stimulate spinal cord neurons after injury, improving locomotor recovery in rats.

This study assesses brain tissue properties and morphometry in chronic complete spinal cord injury patients using MRI, finding significant white matter volume loss linked to Wallerian degeneration but no structural brain changes with conventional analysis.

This study shows that microglia reduce lesion size and improve recovery after spinal cord injury in mice by promoting astroglial encapsulation and limiting inflammation.

This paper develops a deep learning framework with active learning to predict the effects of cervical epidural stimulation on hand function in spinal cord injury patients, achieving 15% prediction error.

This study shows glucocorticoids inhibit spinal cord regeneration by directly affecting ependymal glia, contrasting with zebrafish regeneration mechanisms.