Peripheral Artery Disease Management

Biomechanical Compatibility With Physiological Limb-Flexion Deformation Reduces Inflammation and Neointimal Hyperplasia After Peripheral Stenting

This study shows that a stent designed to better accommodate limb-flexion deformation reduces inflammation and neointimal hyperplasia compared to a standard stent.

A higher polygenic score for peripheral artery disease is associated with younger age at surgery among patients undergoing revascularization

The paper finds a higher polygenic score for PAD is linked to younger age at surgery, replicated in UK Biobank.

Foot perfusion. Insights from an anatomically detailed arterial network model

This paper models foot perfusion during a cuff-induced ischaemia test to assess how arterial occlusions and collateral impairment affect tissue perfusion in different foot regions.

Genome-Wide Association Study of Genetic Variants Associated with Lower Extremity Amputation Risk in Peripheral Artery Disease

This study identifies genetic variants associated with lower extremity amputation risk in peripheral artery disease using GWAS from the All of Us Research Program.

BIOMECHANICAL CHARACTERIZATION OF PORCINE LOWER LIMB ARTERIES FOR PRECLINICAL EVALUATION OF PERIPHERAL VASCULAR DEVICES

This study characterizes the biomechanical properties of porcine lower limb arteries to evaluate their suitability as preclinical models for peripheral vascular devices.

PAD-associated genetic variants are more strongly associated with surgical intervention than premature onset

This study identifies PAD-associated SNPs with stronger associations with surgical intervention than premature onset using UK Biobank data.

EXPERIMENTAL CHARACTERIZATION OF BALLOON ANGIOPLASTY IN HUMAN FEMOROPOPLITEAL ARTERIES WITH DIFFERENT CALCIUM BURDENS

This study characterizes luminal gains and damage after balloon angioplasty in human femoropopliteal arteries with varying calcium burdens using imaging, histology, and mechanical testing.

Generation and Validation of a Lower Limb Muscle Single-Cell RNA Sequencing Data Set Identifies Pathogenic Endothelial Metabolism in Peripheral Arterial Disease

The paper generates and validates a single-cell RNA-seq dataset to identify pathogenic endothelial metabolism in peripheral arterial disease, showing cell-type specific metabolic changes in CLTI.

Mitochondrial Dysfunction in Endothelial Cells Drives Greater Vascular Impairment in Females with Diabetes-Associated Peripheral Artery Disease

This study identifies sex-specific mitochondrial dysfunction in endothelial cells of diabetic PAD patients, showing that MitoQ improves vascular function in females.

An integrated polygenic score stratifies risk of peripheral artery disease and adverse limb events in ancestrally diverse cohorts

This paper develops a polygenic score for peripheral artery disease (PAD) that improves risk prediction across diverse populations and identifies high-risk individuals for adverse limb events.

Evaluation of plasma biomarkers for causal association with peripheral artery disease

This paper evaluates plasma biomarkers for causal association with peripheral artery disease using Mendelian randomization, identifying 19 biomarkers with significant genetic evidence for causality.

Cell state transition analysis reveals a causal network that controls critical limb ischemia

The paper identifies a causal network controlling endothelial cell states in critical limb ischemia using transcriptomics data and cSTAR analysis.

Admixture Mapping of Peripheral Artery Disease in a Dominican Population Reveals a Novel Risk Locus on 2q35

The paper identifies a novel risk locus for PAD on 2q35 in Dominicans using admixture mapping and health systems data.