Endometriosis Research and Treatment

High-Resolution Spatial Transcriptomics Reveals Fibroblast and Neuroimmune Microenvironments in Endometriosis Lesions

This study uses high-resolution spatial transcriptomics to map fibroblast and neuroimmune microenvironments in endometriosis lesions, identifying spatial cellular interactions linked to pain.

A Transcriptomics-Based Computational Drug Repurposing Pipeline Identifies Simvastatin And Primaquine As Therapeutics For Endometriosis

This study identifies simvastatin and primaquine as potential therapeutics for endometriosis through computational drug repositioning, showing reduced pain and gene expression changes in animal models and lower disease risk in EMR data.

The over-activated peritoneal immune environment in endometriosis is characterised by a lack of PD-1 inhibition.

This study identifies reduced PD-1 expression in peritoneal fluid of endometriosis patients, suggesting its role in persistent inflammation and potential as a therapeutic target.

Whole-genome methylation profiling of menstrual stem cells identifies novel biomarkers for endometriosis

The paper identifies DNA methylation biomarkers in menstrual stem cells that distinguish endometriosis from controls with high diagnostic accuracy.

Contributions of T helper 9 cells in endometriosis-associated inflammation and lesion growth

This study investigates the role of Th9 cells in endometriosis by analyzing human tissue samples, in vitro experiments, and a mouse model, finding increased IL-9-positive cells and pro-inflammatory mediators in lesions.

Compound design of a patient-derived 3D cell culture system modelling early peritoneal endometriosis

This paper develops a 3D patient-derived co-culture model of early peritoneal endometriosis to study lesion formation and progression.

Establishment and Characterization of a New Immortalized Human Adenomyosis Epithelial-Like Cell Line, tAEC21

This paper establishes and characterizes a new immortalized human adenomyosis epithelial-like cell line, tAEC21, which exhibits specific marker expression and functional responses relevant to adenomyosis.

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy with Comorbid Traits

This study identifies M2 macrophages and IL1 signaling as key mediators of endometriosis risk and shows their pleiotropic role in comorbid traits.

Mathematical modelling of macrophage and natural killer cell immune response during early stages of peritoneal endometriosis lesion onset

This study develops a mathematical model of immune responses in early endometriosis, showing reduced cytotoxicity and detection ability drive disease onset.

Matrix tropism influences endometriotic cell attachment patterns

The paper investigates how matrix tropism affects endometriotic cell attachment patterns on ovarian tissues.

A Fibronectin (FN)-Silk 3D Cell Culture Model as a Screening Tool for Repurposed Antifibrotic Drug Candidates for Endometriosis

This paper develops a 3D cell culture model using fibronectin-silk matrices to study endometriosis fibrosis and tests pirfenidone as a repurposed antifibrotic drug candidate.

Spatial Transcriptomic Analysis Identifies Epithelium-Macrophage Crosstalk in Endometriotic Lesions

This study uses spatial transcriptomics to identify increased epithelium-macrophage signaling in endometriotic lesions, highlighting a new role for Complement 3 in lesion inflammation.

Platelets as key cells in endometriosis patients: insights from small extracellular vesicles in peritoneal fluid and endometriotic lesions analysis

This study identifies platelet-derived small extracellular vesicles in endometriosis patients, showing increased platelet biomarker-positive EVs in peritoneal fluid.

Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next generation sequencing data analysis

This study identifies key biomarkers for endometriosis using NGS data analysis, revealing 10 hub genes and potential miRNAs and TFs involved in the disease.

Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level

The paper uses single-cell RNA-sequencing to identify distinct metabolic signatures in endometriotic lesions compared to eutopic endometrium, highlighting altered pathways and steroidogenesis-related genes in specific cell types.

N-Myc and STAT Interactor is an endometriosis suppressor.

This study identifies NMI as an endometriosis suppressor by showing its role in enhancing IFN-induced apoptosis and inhibiting proliferation and cell adhesion in endometrial cells.

Characterizing the extracellular matrix transcriptome of endometriosis

This study characterizes the matrisome gene expression in endometriosis using GEO datasets, showing its ability to stratify samples and identify significant gene networks.

Epigenetic age provides insight into tissue origin in endometriosis

The paper uses DNA methylation age to classify endometriosis subtypes by distinguishing between retrograde and non-retrograde origins.

Single cell analysis of endometriosis reveals a coordinated transcriptional program driving immunotolerance and angiogenesis across eutopic and ectopic tissues.

This study uses single-cell transcriptomics to analyze endometriosis, identifying novel cell types and mechanisms in both eutopic and ectopic tissues.

Whole-tissue deconvolution and scRNAseq analysis identify altered endometrial cellular compositions and functionality associated with endometriosis

Is there a neuropathic-like component to endometriosis-associated pain? Results from a large cohort questionnaire study

This study investigates endometriosis-associated pain using a large cohort questionnaire, finding a significant neuropathic-like component in a substantial proportion of patients.