Olfactory and Sensory Function Studies

Odors Smell Like Their Components: A Linear Framework for Predicting Olfactory Mixture Perception

The paper shows that odor mixtures can be predicted linearly from component odorant profiles, challenging the assumption of nonlinear interactions.

Rapid odorant metabolism organizes identity- and timing-based odor representations by olfactory bulb inputs and outputs

The paper shows that rapid odorant metabolism in the olfactory mucosa generates secondary odorants that reshape odor representations by introducing timing-based distinctions between inhaled and internally-generated odorants.

Computationally mapping olfactory receptors to odor percepts using docking energy scores

The paper maps olfactory receptors to odor percepts using docking energy scores, showing a direct relationship between receptors and specific smells.

Acute hypoxia induces transient olfactory dysfunction through olfactory epithelial degeneration and bulbar mitochondrial stress in zebrafish

This study examines the effects of acute hypoxia on the olfactory system of zebrafish, revealing degenerative and regenerative responses in the olfactory epithelium and bulb.

Evidence that Dogs Can Use Temporal Difference in Odorant Arrival to Discriminate Odorant Mixtures

This study shows dogs can detect very short differences in odorant arrival times, distinguishing between synchronous and asynchronous odorant mixtures under natural sampling conditions.

Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb

The paper identifies a non-monotonic concentration-response relationship in mitral/tufted cells of the mouse olfactory bulb, suggesting interglomerular inhibition facilitates odor discrimination.

Distributed representations of chemosensory valence in a naive vertebrate brain

The paper maps chemosensory valence-related neuronal activity in larval zebrafish, showing distributed brain-wide organization rather than localized regions.

Odor preference maps to cohesive transcriptional domains in the olfactory bulb

The paper identifies transcriptional domains in the zebrafish olfactory bulb that correlate with odor preference and shows specific neuronal subtypes are recruited based on odor preference.

Goofy/123Cre Lineage Tracing Differentiates Olfactory and Vomeronasal Neurons from GnRH-1 and Terminal Nerve Neurons During Neuronal Migration and Reveals Additional Olfactory Placode-Derived Cells in the Brain

The paper uses lineage tracing to differentiate olfactory and vomeronasal neurons from GnRH-1 and terminal nerve neurons, revealing genetic heterogeneity and additional olfactory placode-derived cells in the brain.

Canopy1/Cnpy1 is required for proper V2R processing and transport; its loss impairs the function and circuit organization of basal/V2R vomeronasal sensory neurons

This study shows that Cnpy1 is essential for V2R processing and transport in basal vomeronasal sensory neurons, with its loss causing functional impairment and circuit disruption.

Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway

The paper examines how experience transforms olfactory representations along the cortico-hippocampal pathway in mice, showing increased odorant selectivity and population-level representations in hippocampal structures.

Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinct Neuronal Responses to Dominant and Subordinate Cues

This study uses snRNA-seq to identify distinct neuronal responses in the amygdala to dominant and subordinate olfactory cues, revealing specialized glutamatergic and GABAergic populations.

Projection-specific Routing of Odor Information in the Olfactory Cortex

The paper investigates how odor information is routed through feedforward and feedback pathways in the mouse olfactory cortex, finding distinct temporal encoding and plasticity in neurons projecting to different targets.

Bilateral equalization of synaptic output in olfactory glomeruli of Xenopus tadpoles

This study shows that unilateral odor stimulation in Xenopus tadpoles leads to bilateral glomerular potentiation mediated by dopamine, compensating for imbalances in olfactory sensory neuron activity.

Receptor-Anchored Olfaction Representation through Perception-Consistent Metric Learning

This paper introduces RAMS, a framework that uses perceptual consistency to predict olfactory receptor activation spectra, improving accuracy and revealing new insights into OR function.

Decorrelation by gain control in the mouse olfactory bulb

The paper shows that the mouse olfactory bulb decorrelates odour representations from input to output, enhancing separability through gain modulation.

Synaptic inhibition in the accessory olfactory bulb regulates pheromone location learning and memory

This study shows that synaptic inhibition in the accessory olfactory bulb is crucial for pheromone location learning and memory in rodents.

A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain

The paper shows that olfactory receptor expression in the nose follows a spatial code controlled by a retinoic acid gradient, aligning epithelial and brain maps.

Perception and neural representation of intermittent odor stimuli in mice

This study investigates how mice perceive intermittent odor stimuli by analyzing behavioral responses and neural activity in the anterior piriform cortex, finding that respiratory phase modulates perception but limits information acquisition.

Experience and behavior modulate piriform cortex odor representation in freely moving mice

This study shows that odor representation in the piriform cortex of mice changes over time with experience and is modulated by odor investigation behavior.

Decoding Smell from Receptor Structure

The paper trains a deep learning model to predict odorant receptor-ligand interactions using structural and functional data, revealing structural determinants of ligand selectivity.

Reduced vomeronasal receptor diversity and impaired pheromone detection in Tex15 knockout mice

This study shows that Tex15 regulates vomeronasal receptor diversity and pheromone detection in mice, with its absence leading to impaired aggression behaviors.

Temporal sequence geometry enables odor recognition and generalization

The paper shows that odor-evoked neural sequences in the olfactory bulb propagate as wavefronts in a low-dimensional space, enabling perceptual generalization through Hebbian learning.

Fear conditioning biases olfactory sensory neuron frequencies across generations

This study shows that olfactory fear conditioning in mice leads to heritable changes in olfactory neuron frequencies and behavior across generations.

Microglial morphological complexity in the piriform cortex is associated with olfactory aversion following chronic stress

This study shows chronic stress increases microglial complexity in the anterior piriform cortex, correlating with odor avoidance behavior in mice.

Striking olfactory receptor gene repertoire expansion in Senegalese sole (Solea senegalensis)

This study characterizes the expanded olfactory receptor gene repertoire in Senegalese sole, identifying 455 genes and showing functional expression through transcriptome analysis.

Male odor preference in female mice is modulated across reproductive stages via the posteroventral medial amygdala.

The paper investigates how male odor preference in female mice changes across reproductive stages and identifies the posteroventral medial amygdala as critical for suppressing preference during nursing.

Positive olfactory childhood memory is rooted in the olfactory bulb and triggers large scale changes beyond the olfactory system

The paper shows that positive olfactory childhood memories in mice are encoded in the olfactory bulb and involve dynamic changes in brain networks.

Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding

This study shows that efficient coding recovers canonical olfactory features by maximizing mutual information layer-wise under biophysical assumptions.

Grounding olfactory perception in language: Benchmarks and models for generating natural language odor descriptions

ODIEU pairs human odor texts for 10,124 molecules with olfaction-tuned Sentence-BERT evaluators; CIRANO, a frozen GPT-2 with a molecular prefix, generates descriptions approaching human agreement.