Topic · Rheumatology · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
10 papers
Szymon Baluszek, Paulina Kober, Renata Woroniecka, Natalia Maławska, Michał Wągrodzki, Jacek Kunicki, Tomasz Mandat, Beata Grygalewicz, Mateusz Bujko
This paper identifies four genomic clusters in skull base chordoma based on copy-number events, linking them to transcriptional programs and therapeutic implications.
Neoplasia · Jun 12, 2026Peer-reviewedCancer Biology
Giorgia Farinacci, Ilenia Coletta, Biagio Palmisano, Emanuela Spica, Chiara Tavanti, Samuele Di Cristofano, Samantha Donsante, Marta Serafini, Tiziana Borsello, Mary Anna Venneri, Alessandro Corsi, Debora Salerno, Benedetta Donati, Alessia Ciarrocchi, Domenico Raimondo, Mara Riminucci
This study investigates how RANKL inhibition affects bone formation in a mouse model of fibrous dysplasia, finding that bone formation is restricted to specific surfaces rather than occurring diffusely.
Communications Biology · Apr 22, 2026Peer-reviewedPathology
Siddh van Oost, Rick Ursem, Zeynep Betül Erdem, Sara Cardoso, Sanne Venneker, Ruud van der Breggen, Inge H. Briaire‐de Bruijn, Alwine B. Kruisselbrink, Wilco C. Peul, Károly Szuhai, Robert J. P. van der Wal, René J. M. van Zeijl, Bram Heijs, Noel F.C.C. de Miranda, Judith V.M.G. Bovée
This study links immune infiltration in chordomas to increased transcriptional activity and distinct metabolic profiles, but causality remains unclear.
iScience · Apr 9, 2026Peer-reviewedCancer Biology
Biagio Palmisano, Chiara Tavanti, Giorgia Farinacci, Alessandro Corsi, Marta Serafini, Natasha M. Appelman‐Dijkstra, Mara Riminucci
This study evaluates the combination of zoledronate and anti-RANKL therapy in a mouse model of fibrous dysplasia, showing delayed disease rebound and improved bone density.
Journal of Bone and Mineral Research · Feb 22, 2026Peer-reviewedPathology
Charles S. Umbaugh, Marie Groth, Cihan Erkut, Kwang-Seok Lee, Joana Marinho, Simon Linder, Florian Iser, Jonas N. Kapp, Petra Schroeter, Simay Dolaner, Asli Kayserili, Dominic Helm, Martin Schneider, Julia Hartmann, Philipp Walch, , Claudia Scholl
This study uses T-DARPins to inhibit TBXT in chordoma cells, revealing its regulome and identifying therapeutic vulnerabilities, including sensitivity to JAK2 inhibitors.
Science Advances · Sep 3, 2025Peer-reviewedCancer Biology
Marion Lenté, Juliette Aury‐Landas, Mahdia Taieb, Benoı̂t Bernay, Eva Lhuissier, Karim Boumédiene, Catherine Baugé
This study evaluates adenosine analogues for chondrosarcoma treatment, finding that cladribine and clofarabine reduce cell viability and induce apoptosis in vitro and in vivo.
Molecular Therapy — Nucleic Acids · Jul 23, 2025Peer-reviewedCancer Biology
Biagio Palmisano, Chiara Tavanti, Giorgia Farinacci, Giorgio Gosti, Marco Leonetti, Samantha Donsante, Giuseppe Giannicola, Natasha M. Appelman‐Dijkstra, Alessandro Corsi, Ernesto Ippolito, Mara Riminucci
This study shows that bone pain in Fibrous dysplasia is intrinsic and not caused by abnormal sensory nerve sprouting or neuroma formation.
Journal of Bone and Mineral Research · May 3, 2025Peer-reviewedPathology
William C. H. Cross, Iben Lyskjær, Tom Lesluyes, Steven Hargreaves, Anna‐Christina Strobl, Christopher Davies, Sara Waise, Shadi Hames-Fathi, Dahmane Oukrif, Hongtao Ye, Fernanda M Amary, Roberto Tirabosco, Craig Gerrand, Toby M. Baker, David Barnes, , Adrienne Margaret Flanagan
The paper presents a genetic model of central chondrosarcoma using genomic and epigenomic data to identify mutations and methylation patterns associated with patient outcomes.
Genome Medicine · Aug 30, 2022Peer-reviewedGenetic & Genomic Medicine
Paco López‐Cuevas, Luke Deane, Yushi Yang, Chrissy L. Hammond, Érika Kague
The paper shows transformed notochordal cells in zebrafish cause skeletal damage, chronic wound-like responses, and bone homeostasis disruption, linking chordomas to inflammation and IVD degeneration.
Disease Models & Mechanisms · Feb 12, 2021Peer-reviewedDevelopmental Biology
Matthew W. Fittall, Iben Lyskjær, Peter Ellery, Patrick Lombard, Jannat Ijaz, Anna‐Christina Strobl, Dahmane Oukrif, Maxime Tarabichi, Martin Sill, Christian Koelsche, Gunhild Mechtersheimer, Jonas Demeulemeester, Roberto Tirabosco, Fernanda M Amary, Peter J. Campbell, , Adrienne Margaret Flanagan
This study identifies genomic and methylation patterns associated with benign metastases and malignant transformation in giant cell tumour of bone.
The Journal of Pathology · Aug 31, 2020Peer-reviewedGenetic & Genomic Medicine