Sleep and Wakefulness Research

Neuronal firing rates diverge during REM and homogenize during non-REM

The paper examines how neuronal firing rates change during REM and NREM sleep in rats, finding increased variance during REM and homogenization during NREM.

Noninvasive sleep monitoring in large-scale screening of knock-out mice reveals novel sleep-related genes

The paper identifies 122 novel sleep-related genes from a large-scale knockout mouse study using non-invasive sleep monitoring.

Genetics of vaccination-related narcolepsy

The paper identifies genetic risk variants associated with vaccination-related narcolepsy using genomic data from cases and controls.

AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance

This paper shows that AMPK signaling, disrupted by the 1q21.1 deletion, is essential for neuronal integrity, sleep maintenance, and stress survival in Drosophila.

Sleep deprivation selectively up-regulates an amygdala-hypothalamic circuit involved in food reward

This study shows that sleep deprivation increases food reward valuation through hedonic mechanisms, not hormonal changes, using fMRI and behavioral tasks.

Sleep selectively stabilizes contextual aspects of negative memories

The paper examines how sleep affects the retention of negative and neutral memories, finding that sleep selectively stabilizes negative contextual memories.

Improved sleep scoring in mice reveals human-like stages.

This paper introduces a new classification of NREM sleep stages in mice, revealing human-like stages and their association with neuronal activity changes.

Cued reactivation during slow-wave sleep induces connectivity changes related to memory stabilization.

The paper analyzes how auditory cues during slow-wave sleep affect brain network connectivity and memory stabilization.

Harnessing sleep/wake state tracking by olfactory bulb oscillations to perform fully brain-based sleep scoring in mice

This paper develops a brain-based sleep scoring method using olfactory bulb and hippocampal oscillations in mice, achieving high accuracy comparable to EMG and video tracking.

Variable training but not sleep improves consolidation of motor adaptation

The paper investigates whether sleep or training variability affects motor adaptation consolidation, finding that higher training variability improves retest performance, correlating with alpha power in parietal areas.

Targeted memory reactivation during sleep to strengthen memory for arbitrary pairings

The paper tests if targeted memory reactivation during sleep can improve memory for object pairs, finding better recall for cued objects than non-cued ones.

Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice

This study examines how disrupting the Hcrtr1 gene in noradrenergic neurons affects theta and gamma oscillations in different arousal contexts, revealing context-dependent changes in brain activity.

Theta phase coordinated memory reactivation reoccurs in a slow-oscillatory rhythm during NREM sleep

The paper shows that memory reactivation patterns reoccur during NREM sleep at a 1 Hz slow oscillatory rhythm, coordinated by theta oscillations.

Rapid, noninvasive, and unsupervised detection of sleep/wake using piezoelectric monitoring for pharmacological studies in narcoleptic mice

This paper introduces PiezoSleep, a noninvasive method to detect sleep/wake in narcoleptic mice, showing it can identify phenotypes and screen drugs efficiently.

Theta bursts precede, and spindles follow, cortical and thalamic downstates in human NREM sleep

The paper identifies theta bursts preceding and spindles following cortical and thalamic downstates in human NREM sleep, suggesting theta bursts may trigger downstates and aid memory consolidation.

Feature-specific awake reactivation in human V1 after visual training

The paper shows that specific visual features, like Gabor orientation, are reactivated in human V1 after visual training, and this reactivation correlates with performance improvement.

Large-Scale Structure and Individual Fingerprints of Locally Coupled Sleep Oscillations

The paper characterizes the spatial and temporal dynamics of slow oscillation-spindle coupling during sleep and finds individual variability in coupling phase that is stable across nights but not linked to memory change.

Sleep and Motor Control by a Basal Ganglia Circuit

This study identifies a basal ganglia circuit involving SNr and STN neurons that regulates sleep and motor control by modulating behavioral transitions.

Functional determinants of enhanced and depressed inter-areal information flow in NREM sleep between neuronal ensembles in rat cortex and hippocampus

The paper examines how information flow between brain regions changes during non-REM sleep in rats, finding that task-related neurons show increased short-time communication while non-task neurons show increased long-time communication.

The effect of dream report collection and dream incorporation on memory consolidation during sleep

This study examines how dream report collection and task incorporation during sleep affect memory consolidation, finding that NREM sleep dreams are linked to improved task performance.

Competitive learning modulates memory consolidation during sleep.

This study shows that memory consolidation during sleep involves competition and selective weakening, with beta power indicating competition-based forgetting and sigma power indicating memory strengthening.

Rapid Eye Movement sleep deprivation of rat generates ROS in the hepatocytes and make them more susceptible to oxidative stress

This study shows that REM sleep deprivation in rats increases ROS levels and oxidative stress in hepatocytes, with elevated iNOS and NO, which normalize after recovery sleep.

Electrophysiological characterization and MCH/orexin neuronal distribution in the lateral hypothalamus of naked mole-rats (Heterocephalus glaber)

This study characterizes electrophysiological properties and MCH/HO neuronal distribution in the lateral hypothalamus of naked mole-rats, finding similarities to mice but distinct distribution patterns.

Narcolepsy type 1 patients have abnormal brain activation to neutral-rated movies in humor-paradigm

This study finds that narcolepsy type 1 patients show increased brain activation to neutral-rated movies compared to controls, suggesting altered humor processing and potential links to cataplexy mechanisms.

Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.

Differential roles of sleep spindles and sleep slow oscillations in memory consolidation

This study shows sleep spindles and slow oscillations each play distinct roles in memory consolidation, with spindles enabling independent memory replay and slow oscillations favoring strong memories, as observed in natural sleep.

Overnight memory consolidation facilitates rather than interferes with new learning of similar materials - a study probing NMDA-receptors

The paper investigates how overnight memory consolidation affects new learning of similar materials, finding that consolidation facilitates rather than interferes with learning, and that D-cycloserine enhances new learning independently of sleep.

Differential role of prefrontal and parietal cortices in controlling level of consciousness

The paper shows that cholinergic stimulation of the prefrontal cortex restores wakefulness in anesthetized rats, while noradrenergic stimulation does not.

Partial ablation of the orexin field induces a sub narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration

This study shows that partial orexin neuron loss in mice leads to a sub-narcoleptic phenotype with compensatory wake-promotion, resembling narcolepsy type 2.

Standing Sentinel during Human Sleep: Continued Evaluation of Environmental Stimuli in the Absence of Consciousness

The paper evaluates how environmental stimuli are processed during different sleep stages, finding that voice familiarity assessment continues during sleep and that sleep spindles and slow oscillations modulate stimulus processing based on salience.