Sleep and Wakefulness Research

Coordination of human hippocampal sharpwave-ripples during NREM sleep with cortical theta bursts, spindles, downstates and upstates

This study shows that human hippocampal sharpwave-ripples (HC-SWR) are correlated with various cortical sleep waves during NREM sleep, with specific spatial and temporal preferences.

Posterior hippocampal spindle-ripples co-occur with neocortical theta-bursts and down-upstates, and phase-lock with parietal spindles during NREM sleep in humans

The paper identifies distinct physiological patterns of hippocampal spindle-ripples in humans, showing they differ from sharpwave-ripples in timing, cortical coupling, and frequency.

The neuropeptide Galanin is required for homeostatic rebound sleep following increased neuronal activity

This study identifies Galanin as essential for rebound sleep following increased neuronal activity in zebrafish.

Arousal-State Dependent Alterations in VTA-GABAergic Neural Activity

This study investigates how VTA-GABAergic neurons change their activity across sleep/wake states and in response to stimuli, showing distinct correlations with cortical oscillations compared to dopaminergic neurons.

Heterogeneous profiles of coupled sleep oscillations in human hippocampus

This study characterizes cross-frequency coupling in human hippocampal sleep oscillations during NREM and REM sleep using intracranial and scalp recordings.

Longitudinal increase in sleep problems is related to amyloid deposition in cortical regions with high HOMER1 gene expression

The paper examines the relationship between sleep problems and amyloid deposition in cortical regions with high HOMER1 expression in older adults, finding a stronger link in younger participants and regions with high HOMER1 expression.

Ca2+ signaling in astrocytes is sleep-wake state specific and modulates sleep

This study identifies sleep-wake specific astrocytic Ca2+ signaling and its role in modulating sleep transitions and stability.

Opponent neurochemical and functional processing in NREM and REM sleep in visual learning

The paper measures neurochemical balance during sleep stages and finds NREM sleep increases plasticity for performance gains while REM sleep stabilizes learning post-training.

Neural dynamics of associative learning during human sleep

This study investigates neural dynamics during human sleep-learning, finding delta and sigma activity in early stages and theta activity in later stages of associative learning.

A role for astroglial calcium in mammalian sleep

The paper shows astroglial calcium concentrations change with sleep and wake states, and mediate sleep need by affecting the homeostatic response to sleep deprivation.

Microfluidic-Induced Sleep: A Spontaneous C. elegans Sleep State Regulated by Satiety, Thermosensation and Mechanosensation

The paper identifies a spontaneous sleep-like state in C. elegans induced by microfluidic confinement, regulated by satiety, thermosensation, and mechanosensation.

The paradox of Rapid Eye Movement sleep in the light of oscillatory activity and functional synchronization during phasic and tonic microstates

This study identifies two distinct microstates within REM sleep, phasic and tonic, showing different patterns of cortical oscillations and synchronization.

Dynamic changes in cerebral and peripheral markers of glutamatergic signaling across the human sleep-wake cycle

The paper examines changes in cerebral and peripheral markers of glutamatergic signaling across the human sleep-wake cycle and finds that sleep loss increases glutamate and mGluR5 availability, which normalize with recovery sleep.

Phase discontinuities underlie increased drowsiness and diminished sleep quality in older humans

This paper introduces a phase discontinuity measure to assess sleep quality, finding increased phase discontinuity correlates with drowsiness, reduced deep sleep, and impaired REM sleep in older adults.

Targeted memory reactivation during sleep elicits neural signals related to learning content

The paper decodes memory reactivation content from sleep EEG, showing lateralized signals predict memory stabilization and correlate with spindles.

Timing between cortical slow oscillations and heart rate bursts during sleep predicts perceptual speed, but not offline consolidation

Excitable dynamics of NREM sleep: a unifying model for neocortex and hippocampus

The paper develops a mean field model to explain NREM sleep dynamics in the neocortex and hippocampus, showing they alternate between stable and transient states.

Dissociating orexin-dependent and -independent functions of orexin neurons using novel orexin-Flp knock-in mice

This study uses orexin-Flp knock-in mice to distinguish orexin-dependent and -independent functions of orexin neurons, finding orexin is essential for sustained arousal and basic neuronal properties.

GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice

This study identifies VTAGad67+ GABAergic neurons as key regulators of NREM sleep in mice through chemogenetic and optogenetic manipulations and electrophysiological recordings.

State-Switching Probability Reveals Sleep-Related Biological Drives in Drosophila

The paper introduces a method to measure sleep pressure and depth in Drosophila using movement data without disrupting behavior, showing these parameters are independent and influence total sleep.

Rapid sensory integration in orexin neurons governs probability of future movements

This study shows orexin/hypocretin neurons rapidly control movement by integrating sensory input and initiating locomotion.

Individual slow wave morphology is a marker of ageing

This study shows that detailed slow wave morphology, beyond standard parameters, is linked to age and cognitive decline, suggesting it as a biomarker for ageing.

Visual imagery and visual perception induce similar changes in occipital slow waves of sleep

The paper shows that visual experience during wakefulness affects slow wave activity in the occipital cortex during sleep, with internal visual imagery modulating these changes.

Sleep restriction caused impaired emotional regulation without detectable brain activation changes - a functional magnetic resonance imaging study

This study investigates how sleep restriction affects emotional regulation using fMRI, finding increased prefrontal cortex activity in young participants but no brain activation changes in either age group.

Precise Slow Oscillation-Spindle Coupling Promotes Memory Consolidation in Younger and Older Adults

This study examines age-related changes in slow oscillation-spindle coupling during sleep and its role in memory consolidation across adulthood.

Regional low-frequency oscillations in human rapid-eye movement sleep

The paper identifies two types of low-frequency oscillations in human REM sleep and links them to distinct functional roles and generation mechanisms.

Cold Inducible RNA-binding protein (CIRBP) adjusts clock gene expression and REM sleep recovery after sleep deprivation

This study shows that CIRBP modulates clock gene expression and REM sleep recovery after sleep deprivation in mice.

Most sleep does not serve a vital function. Evidence from Drosophila melanogaster

This study investigates sleep function in Drosophila melanogaster, finding that sleep restriction is not lethal and that circadian drive, not homeostasis, primarily drives sleep pressure.

BOLD signatures of sleep

This paper identifies BOLD oscillations in fMRI that differentiate sleep from wake and correlate with spindles and slow waves.

REM sleep: unique associations with behavior, corticosterone regulation and apoptotic pathways in chronic stress in mice

This study identifies REM sleep as a core response to chronic stress in mice, linking it to corticosterone regulation and apoptotic pathways through transcriptomic analysis.