Complement system in diseases

A novel mouse model expressing human forms for complement receptors CR1 and CR2

This paper creates a mouse model expressing human CR1 and CR2 variants to study their role in disease.

Mannose-binding lectin gene polymorphisms in the East Siberia and Russian Arctic populations

The paper genotypes MBL2 gene polymorphisms in four Russian Arctic populations and finds significant differences in allele frequencies compared to Russians and European populations.

Deficiency of complement component C1Q prevents cerebrovascular damage and white matter loss in a mouse model of chronic obesity

This study shows that deficiency of C1QA prevents cerebrovascular damage and white matter loss in obese mice, suggesting a role for the complement cascade in obesity-induced brain pathology.

Complement in human pre-implantation embryos: attack and defense

The paper analyzes complement molecule expression and deposition in human pre-implantation embryos, showing complement activation and defense mechanisms at early stages of development.

Thirty five novel nsSNPs may affect ADAMTS13 protein leading to Thrombotic thrombocytopenic purpura (TTP) using bioinformatics approach

The paper predicts 35 novel nsSNPs in ADAMTS13 that may cause TTP using bioinformatics tools.

Molecular crypsis by pathogenic fungi using human factor H. A numerical model

The paper presents a mathematical model of molecular crypsis by pathogenic fungi using human factor H, finding that pathogen abundance relative to host cells determines the success of crypsis and potential autoreactivity.

Cell type-specific complement expression from healthy and diseased retinae

The paper identifies cell type-specific complement expression patterns in healthy and diseased retinas across human and murine models, highlighting age-related and disease-induced changes.

The complement system supports normal postnatal development and gonadal function in both sexes

The paper identifies CSMD1 variants linked to gonadal function in both sexes and shows that Csmd1 knockout mice have reproductive defects, implicating the complement system in postnatal development.

Reduced order modeling and analysis of the human complement system

The paper develops a reduced order mathematical model of the human complement system that is predictive and computationally efficient, showing that multiple therapeutic targets are needed to disrupt complement activation.