Chronic Lymphocytic Leukemia Research

IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas

This study identifies IL-16 production as a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas, showing that targeting the IL-16/CD9 axis restores drug sensitivity.

Targeting of ibrutinib resistance driving pathways by miR-28 in ABC-DLBCL

This study shows miR-28 inhibits ibrutinib resistance in ABC-DLBCL by targeting mitochondrial and mTOR pathways and improves survival in treated patients.

Systemic MIF facilitates chronic lymphocytic leukemia development independent of its cellular source

This study shows that systemic MIF is critical for CLL development, regardless of its cellular source, as Mif-deficient hosts resist disease despite adaptive transfer of CLL cells.

Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture

The paper compares macrophage feeder systems to assess their effects on chronic lymphocytic leukemia cells, including phagocytosis, treatment resistance, and transcriptional changes.

IGLV3-21-R110-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia

This study develops bispecific antibodies targeting IGLV3-21R110 to selectively kill high-risk CLL cells while sparing healthy B cells and stem cells.

Understanding the Role of Toggle Genes in Chronic Lymphocytic Leukemia Proliferation

The paper analyzes RNA-Seq data of CLL cells to identify toggle genes and temporal differentially expressed genes, showing their role in cell-state transitions and population plasticity.

Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotype and phenotype in chronic lymphocytic leukemia

This study uses long-read scRNA-seq to analyze cancer subclone-specific mutations and transcriptomic differences in CLL patients with BTKC481S mutations.

Comprehensive Characterization of BTK Inhibitor Specificity, Potency, and Biological Effects: Insights into Covalent and Non-covalent Mechanistic Signatures

This paper characterizes the potency, selectivity, and biological effects of fifteen BTK inhibitors, revealing differences between covalent and non-covalent inhibitors in binding affinity and off-target effects.

A Systems Biology Analysis of Chronic Lymphocytic Leukemia

This paper identifies key proteins in CLL using statistical thermodynamics and systems biology, advocating for multi-target inhibition strategies to improve therapy design.

Nucleosome repositioning in chronic lymphocytic leukaemia

This study identifies changes in nucleosome positioning and packing in chronic lymphocytic leukaemia, linking them to epigenetic mechanisms and patient stratification.

Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

The paper examines changes in transcription start sites and promoter usage in TCL1-driven CLL, identifying N-terminally altered epigenetic regulators and a translation stress signature.

Differential genomic and transcriptomic events associated with high-grade transformation of Chronic Lymphocytic Leukemia

The paper identifies genomic and transcriptomic changes in CLL transforming to RS, finding pathway mutations and non-coding mutations in PAX5 enhancers associated with transformation.