Chronic Lymphocytic Leukemia Research

A multiscale pharmacokinetic-Boolean modelling framework for ibrutinib resistance in a Chronic Lymphocytic Leukaemia case study

This paper develops a multiscale framework linking pharmacokinetics and Boolean models to study ibrutinib resistance in CLL, identifying key regulons and synergistic targets.

BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

Retrotransposon Activity in Chronic Lymphocytic Leukemia: Associations with RNA Splicing and TP53 Dysfunction

This study investigates the relationship between TP53 dysfunction, LINE-1 retrotransposon activity, and transcriptomic changes in CLL, finding that retrotransposons influence RNA splicing rather than causing DNA damage.

The CD19-4-1BBL antibody fusion protein unleashes the immune system against high-risk chronic lymphocytic leukemia

This paper investigates the antileukemic effects of CD19-4-1BBL in chronic lymphocytic leukemia, showing it mitigates immunosuppression and enhances CD8+ T-cell immunity in preclinical models.

IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas

This study identifies IL-16 production as a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas, showing that targeting the IL-16/CD9 axis restores drug sensitivity.

MYC overexpression drives poor prognosis and differential sensitivity to treatments according to TP53 status in chronic lymphocytic leukemia

This study shows that MYC overexpression in CLL worsens prognosis and treatment response, with different effects based on TP53 status.

Targeting of ibrutinib resistance driving pathways by miR-28 in ABC-DLBCL

This study shows miR-28 inhibits ibrutinib resistance in ABC-DLBCL by targeting mitochondrial and mTOR pathways and improves survival in treated patients.

CaMKK2 Identifies Biologically Aggressive Chronic Lymphocytic Leukemia and Regulates Leukemic Survival and Nurse-Like Cell Support

This paper identifies CaMKK2 as a prognostic biomarker for aggressive chronic lymphocytic leukemia and shows its functional role in leukemic survival and nurse-like cell support.

Cancer pathway connectivity resolved by drug perturbation and RNA sequencing

The paper uses drug perturbations and RNA sequencing to map pathway connectivity in CLL, showing how genetic aberrations modulate drug responses and pathway interactions.

Systemic MIF facilitates chronic lymphocytic leukemia development independent of its cellular source

This study shows that systemic MIF is critical for CLL development, regardless of its cellular source, as Mif-deficient hosts resist disease despite adaptive transfer of CLL cells.

Disruption of Marrow Microenvironments in Chronic Lymphocytic Leukemia by High-Resolution Synchrotron Micro-Computed Tomography

This study uses synchrotron micro-CT to quantify microstructural changes in CLL marrow, finding reduced lacuna density and increased adipose surface area linked to disease burden and therapy response.

Reduced CSF1R expression in myeloid cells has limited impact on chronic lymphocytic leukemia progression

This study shows that reducing CSF1R expression in myeloid cells has limited impact on CLL progression, suggesting that targeting CSF1R alone may not be effective for therapy.

Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture

The paper compares macrophage feeder systems to assess their effects on chronic lymphocytic leukemia cells, including phagocytosis, treatment resistance, and transcriptional changes.

Continuous DNA Methylation Deconvolution-Based Surrogate for B-Cell Differentiation State in CLL

The paper develops a continuous DNA methylation metric (B-Index) to classify CLL subtypes and identifies epigenetic signals linked to B-cell differentiation and tumor burden.

IGLV3-21-R110-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia

This study develops bispecific antibodies targeting IGLV3-21R110 to selectively kill high-risk CLL cells while sparing healthy B cells and stem cells.

Asymmetric induction of IL-23R by CpG and IL-15 in proliferative CLL fractions highlights intraclonal heterogeneity in chronic lymphocytic leukemia

The paper shows that CpG and IL-15 induce IL-23R in CLL cells, with proliferative subfractions showing higher expression, suggesting a pathogenic mechanism.

Understanding the Role of Toggle Genes in Chronic Lymphocytic Leukemia Proliferation

The paper analyzes RNA-Seq data of CLL cells to identify toggle genes and temporal differentially expressed genes, showing their role in cell-state transitions and population plasticity.

Time-series RNA-Seq and data-driven network inference unveil dynamics of cell activation, survival and crosstalk in Chronic Lymphocytic Leukaemia in vitro models

The paper uses time-series RNA-Seq and gene regulatory network inference to study how CLL cells respond to immune signals in vitro, revealing dynamic regulatory mechanisms and patient-specific gene modules.

Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotype and phenotype in chronic lymphocytic leukemia

This study uses long-read scRNA-seq to analyze cancer subclone-specific mutations and transcriptomic differences in CLL patients with BTKC481S mutations.

Comprehensive Characterization of BTK Inhibitor Specificity, Potency, and Biological Effects: Insights into Covalent and Non-covalent Mechanistic Signatures

This paper characterizes the potency, selectivity, and biological effects of fifteen BTK inhibitors, revealing differences between covalent and non-covalent inhibitors in binding affinity and off-target effects.

Evolution of chronic lymphocytic leukemia after allogeneic stem cell transplant

This study examines how allogeneic stem cell transplant affects subclonal evolution in chronic lymphocytic leukemia, identifying cellular homogeneity as a biomarker for immune response.

Trogocytosis-mediated transfer of FOLR2 from nurse-like cells to CLL cells is associated with their activation and proliferation

This study shows CLL cells acquire FOLR2 from nurse-like cells via trogocytosis, enhancing their survival and proliferation in vitro.

CCL19⁺ fibroblasts define a proliferative niche in chronic lymphocytic leukemia

The paper identifies CCL19⁺ fibroblasts as a proliferative niche in chronic lymphocytic leukemia by analyzing single-cell RNA sequencing data and characterizing interactions within lymph nodes.

Merkel cell carcinoma-derived macrophage migration inhibitory factor (MIF) may promote persistence of Chronic Lymphocytic Leukemia

The paper shows that Merkel cell carcinoma produces MIF, which supports CLL persistence through CD74 and CXCR4 activation, explaining why CLL blood counts normalize after MCC treatment.

A Systems Biology Analysis of Chronic Lymphocytic Leukemia

This paper identifies key proteins in CLL using statistical thermodynamics and systems biology, advocating for multi-target inhibition strategies to improve therapy design.

Nucleosome repositioning in chronic lymphocytic leukaemia

This study identifies changes in nucleosome positioning and packing in chronic lymphocytic leukaemia, linking them to epigenetic mechanisms and patient stratification.

Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

The paper examines changes in transcription start sites and promoter usage in TCL1-driven CLL, identifying N-terminally altered epigenetic regulators and a translation stress signature.

Identification of splicing defects caused by novel exonic mutations in LEF1 in Sudanese B- chronic lymphocytic leukemia patients: computational approach

The paper identifies novel exonic mutations in LEF1 in Sudanese B-CLL patients and predicts their potential to cause splicing defects using in silico analysis.

Prediction of therapy outcomes of CLL using gene expression intensity, clustering, and ANN classification of single cell transcriptomes

The paper uses gene expression, clustering, and ANN classification of single-cell transcriptomes to predict therapy outcomes in CLL patients.

Temporal variation in lymphocyte proteomics

This study investigates proteomic changes in CLL during the asymptomatic stage using small sample sizes and highlights the need for larger control populations sampled over time.