Advanced Neuroimaging Techniques and Applications

TractoInferno: A large-scale, open-source, multi-site database for machine learning dMRI tractography

TractoInferno provides a large-scale, multi-site database for benchmarking machine learning tractography methods using standardized data and evaluation protocols.

More than just axons: A positive relationship between an intracellular isotropic diffusion signal and pubertal development in white matter regions in a massive adolescent cohort

Mapping neuroinflammation in vivo with diffusion-MRI in rats given a systemic lipopolysaccharide challenge

This study uses diffusion MRI to detect neuroinflammation in vivo in rats after a lipopolysaccharide challenge, showing diffusivity changes correlate with microglial morphology.

An automated pipeline for extracting quantitative histological metrics for voxelwise MRI-histology comparisons

This paper introduces an automated pipeline to extract quantitative histological metrics for voxelwise MRI-histology comparisons and finds activated microglia strongly predicts DTI FA, suggesting diffusion MRI sensitivity to neuroinflammation.

Diffusion MRI Anisotropy in the Cerebral Cortex is Determined by Unmyelinated Tissue Features

This study shows that dMRI-FA in the cerebral cortex is primarily influenced by unmyelinated tissue features rather than myelinated axons.

Tissue Optimisation Strategies for High Quality Ex Vivo Diffusion Imaging

This paper develops an optimization strategy for ex vivo diffusion imaging in rodent brains to improve signal-to-noise ratio and reduce acquisition time.

Age-related changes in brain metabolites underlie slowing of speed-accuracy trade-off

This study investigates age-related changes in brain metabolites and microstructure that contribute to slower response times in older adults.

Clustering laminar cytoarchitecture: in vivo parcellation based on cortical granularity

The paper clusters cortical microstructural datasets using an algorithm adapted from cell omics profiling, validating T1 relaxometry as a tool for exploring cortical laminar composition.

Mapping the "missing" pathways of the anterior cingulate cortex in the human brain

The paper identifies anatomical pathways between the ACC, insula, and vlPFC in humans using NHP data to address dMRI limitations.

Deciphering the developmental order and microstructural patterns of early white matter pathways in a diffusion MRI based fetal brain atlas

This study constructs a Chinese fetal brain diffusion MRI atlas using FOD-based methods, revealing non-monotonic microstructural changes and developmental order of white matter tracts.

Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space

This paper introduces a framework to study brain ontogeny and phylogeny by integrating connectivity maps across species and developmental stages.

Mapping Pontocerebellar Connectivity with Diffusion MRI

This study maps pontocerebellar connectivity using diffusion MRI tractography, revealing a rostral-to-caudal gradient in the pons associated with non-motor and motor cerebellar lobules.

Neurodevelopmental Patterns of Early Postnatal White Matter Maturation Represent Distinct Underlying Microstructure and Histology

The paper uses NMF on MRI data to identify white matter maturation patterns in newborns, showing distinct microstructural and histological features.

An open, analysis-ready, and quality controlled resource for pediatric brain white-matter research

The paper curates and provides analysis-ready diffusion MRI data for pediatric brain white-matter research, including automated quality control using a trained neural network.

Axisymmetric diffusion kurtosis imaging with Rician bias correction: A simulation study

This study compares axisymmetric diffusion kurtosis imaging with and without Rician bias correction, finding that the combination improves parameter estimation accuracy at low SNRs.

Imaging crossing fibers in mouse, pig, monkey, and human brain using small-angle X-ray scattering

This paper demonstrates the use of small-angle X-ray scattering (SAXS) to detect myelinated axon crossings in multiple species, providing a ground truth for validating other imaging methods.

White matter microstructure shows sex differences in late childhood: Evidence from 6,797 children

The paper examines sex differences in white matter microstructure in children using DTI and RSI metrics, finding significant and replicable differences across brain regions.

Sensory processing sensitivity and axonal microarchitecture: Identifying brain structural characteristics for behavior

The paper correlates sensory processing sensitivity proxy scores with diffusion tensor imaging measures in a large sample, identifying axonal microstructural differences associated with SPS traits.

Anatomical connectivity along the anterior-posterior axis of the human hippocampus: new insights using quantitative fibre-tracking.

This study uses quantitative fibre-tracking to map anatomical connectivity along the anterior-posterior axis of the human hippocampus, revealing distinct cortical connections and dense connectivity regions.

Comparison of individualized behavioral predictions across anatomical, diffusion and functional connectivity MRI

This study compares the ability of anatomical, diffusion, and functional MRI to predict individual behavioral measures, finding that functional connectivity provides the best predictions, especially for cognition.

An open MRI dataset for multiscale neuroscience

The paper shares a multimodal MRI dataset for studying multiscale brain organization, including connectomes and gradients from multiple imaging modalities.

Conduction velocity along a key white matter tract is associated with autobiographical memory recall ability

The paper links conduction velocity in the parahippocampal cingulum bundle to autobiographical memory recall ability in healthy adults using MR g-ratio measurements.

On the performance of multi-compartment relaxometry for myelin water imaging - Intra-subject and inter-protocol reproducibility

This paper evaluates the reproducibility of multi-compartment relaxometry for myelin water imaging across different protocols and optimizes acquisition settings to reduce scan time.

A whole-brain 3D myeloarchitectonic atlas: mapping the Vogt-Vogt legacy to the cortical surface

The paper presents a whole-brain 3D myeloarchitectonic atlas based on historical histological data, validated with MRI markers and integrated into neuroimaging software.

Tract-specific white matter microstructure alterations among young adult APOE ε4 carriers: A replication and extension study

This study replicates and extends previous findings on white matter microstructure in young APOE ε4 carriers, finding no PHCB differences but altered ILF asymmetry.

Characterization of b-value dependent T2 relaxation rates for probing neurite microstructure

This paper introduces a method to model combined relaxation diffusion MRI data by characterizing b-value dependent T2 relaxation rates to improve neurite microstructure characterization.

Is adiposity associated with white matter microstructural health and intelligence differently in men and women?

This study examines how adiposity relates to white matter microstructural health and intelligence, finding sex differences in these associations.

Mapping the subcortical connectome using in vivo diffusion MRI: feasibility and reliability

This study assesses the feasibility and reliability of mapping the subcortical connectome using in vivo diffusion MRI tractography and test-retest data from the Human Connectome Project.

Auditory corticostriatal connections in the human brain

This study maps human auditory corticostriatal connections using high-resolution diffusion MRI, finding preferential connectivity between primary auditory cortex and putamen, but not caudate.

Estimating axial diffusivity in the NODDI model

This paper estimates axial diffusivity in the NODDI model using high b-value data and shows the impact of noise assumptions on parameter estimates.