Sarcoidosis and Beryllium Toxicity Research

mTORC1-Dependent Regulation of the CCL24-CCR3 Axis Controls Granuloma Formation and Maintenance in Sarcoidosis

This study identifies mTORC1's role in regulating the CCL24-CCR3 axis, showing its impact on granuloma formation and maintenance in sarcoidosis, with therapeutic implications.

The metabolic profile of Extracellular Vesicles identifies and separates patients with Sarcoidosis and Anti-Synthetase Syndrome

The study identifies distinct metabolic profiles in extracellular vesicles from sarcoidosis patients compared to anti-synthetase syndrome and healthy controls using metabolomic analysis.

Ancestry-specific rewiring of BCR-MAPK signaling in sarcoidosis B cells

This study uses single-cell RNA sequencing to show ancestry-specific B cell signaling changes in sarcoidosis, with more differentially expressed genes in African ancestry patients.

Spatial transcriptomics uncovers hybrid, pro-inflammatory and pro-fibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis

This study uses spatial transcriptomics to identify hybrid pro-inflammatory and pro-fibrotic cellular niches in sarcoidosis granulomas, linking them to fibrosis and immune responses.

New proteomic biomarkers identified in plasma extracellular vesicles in sarcoidosis: a case-control matched study

This study identifies 97 plasma extracellular vesicle proteins as biomarkers for sarcoidosis using proteomics and machine learning, with 13 showing high diagnostic accuracy.

Sarcoidosis resolvers and progressors demonstrate distinct systemic metabolomic profiles

The paper compares metabolomic profiles between sarcoidosis resolvers, progressors, and healthy controls to identify distinct metabolic signatures associated with disease outcomes.

Plasma Proteomic Profiling Reveals Distinct Signatures of Chest CT Phenotypes in Sarcoidosis

This study identifies distinct plasma proteomic signatures associated with different chest CT-defined phenotypes in sarcoidosis, linking them to specific molecular pathways and immune activity.

Single Cell Transcriptome Signatures of Sarcoidosis in Lung Immune Cell Populations

The paper identifies cell-specific molecular changes in sarcoidosis by analyzing single-cell RNA-seq data from lung immune cells, revealing distinct macrophage subpopulations and altered gene expression patterns associated with disease progression.

Unraveling genetic mysteries: phenotype-shaping profiles in chronic sarcoidosis

The paper identifies genetic variants associated with chronic sarcoidosis phenotypes using genome-wide association studies and functional analysis.

Multi-Omic Signatures of Sarcoidosis and Progression in Bronchoalveolar Lavage Cells

The paper integrates DNA methylation, mRNA, and miRNA data from bronchoalveolar lavage cells to identify molecular signatures of sarcoidosis and disease progression.