Neuroscience and Neural Engineering

Microembossing Hydrogel Meso-Circuits for Patterning Dissociated Neurons Promotes Ensemble Formation

This paper introduces a hydrogel-based method to pattern dissociated neurons into multi-scale networks, showing that connectivity paradigms influence ensemble dynamics.

Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates

The paper uses a finite element model to predict tissue strain from micromotion in Utah arrays and correlates these strains with electrode performance in humans and non-human primates.

Focal Infrared Neural Stimulation Propagates Dynamical Transformations in Auditory Cortex

This study investigates how infrared neural stimulation (INS) affects local field potentials in the auditory cortex of rats, revealing frequency-specific entrainment and nonlinear oscillations.

Astrocyte-Guided Maturation of Neural Constructs in a Modular Biosynthetic Hydrogel for Biohybrid Neurotechnologies

This paper develops a modular biosynthetic hydrogel that supports astrocyte-guided neural network formation and functional integration with brain tissue.

PEDOT:PSS conducting eutectogel for enhanced electrical recording and stimulation in implantable neural interfaces

This paper introduces a PEDOT:PSS-based eutectogel for neural interfaces, showing improved impedance and charge injection capacity in vitro and enhanced electrophysiology in vivo.

Beyond retinotopy: exploiting native visual representations in cortical neuroprostheses for vision loss remediation

This paper improves visual prosthetics by incorporating orientation selectivity with retinotopy to better match natural neural responses in the visual cortex.

Ultraflexible, Biodegradable ECoG Arrays via Rapid Fabrication Enables High-Resolution Cortical Mapping and Seizure Network Classification In Vivo

This paper introduces a biodegradable ECoG array with high electrode density and fidelity, demonstrating its ability to map cortical seizures and classify seizure stages with high accuracy in vivo.

Graphene nanoedge electronics for monolithic and chronic recording of local microcircuits at neuronal density

This paper introduces a graphene-based probe for high-density, long-term neuronal recording at neuronal density, demonstrating reliable signal capture and connectivity analysis in vivo.

Engineering Cortical Networks: An Open Platform for Controlled Human Circuit Formation and Synaptic Analysis In vitro

The paper introduces an open platform for creating functional cortical circuits using iPSC-derived neurons, enabling controlled network assembly and analysis of synaptic activity and connectivity.

A clinical grade neurostimulation implant for hierarchical control of physiological activity

This paper introduces a clinical-grade neurostimulation implant that adapts its therapy based on time-of-day to improve closed-loop treatment of neurological disorders.

A Hybrid Knowledge- and Data-driven Model for Automatic Assessment of Induced Spiking Patterns in C-fiber Microneurography: Methodological Development

This paper develops a hybrid model for spike sorting in C-fiber microneurography, achieving better F1-scores and fewer false positives than Spike2 software.

DeviceAgent: An autonomous multimodal AI agent for flexible bioelectronics

DeviceAgent is an AI agent that integrates LLMs and VLMs to automate bioelectronics research tasks, demonstrating capabilities in design, fabrication, defect inspection, and electrophysiological analysis.

Flexible modeling of large-scale neural network stimulation: electrical and optical extensions to The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX)

The paper extends the VERTEX tool to simulate diverse neural stimulation techniques, including electric and optogenetic methods, enabling comprehensive testing of stimulation protocols.

Curved flexible neural interfaces for laminar electrophysiology in deep-brain structures

This paper introduces a curved flexible neural interface for laminar electrophysiology in deep-brain structures, demonstrating stable recordings in the ventral hippocampus over four weeks.

Supervised Spike Sorting Feasibility of Noisy Single-Electrode Extracellular Recordings: Systematic Study of Human C-Nociceptors recorded via Microneurography

The paper evaluates supervised spike sorting for noisy single-electrode recordings from human C-nociceptors, finding raw signal features outperform complex methods and recommending tailored approaches.

Neuralace: Manufacture, Parylene-C Coating, and Mechanical Properties

This paper evaluates the mechanical properties of Neuralace, a novel subdural electrode array, showing how design factors affect stiffness and demonstrating its potential for chronic neural implants.

Intracortical Microstimulation Induces Rapid Microglia Process Convergence

This study shows that intracortical microstimulation rapidly induces microglia process convergence and increases vascular dye penetration, without correlating with electric field strength.

Physiological activity within peripheral nerves influences neural output in response to electrical stimulation: an in vivo study

The paper investigates how electrical stimulation affects neural output in peripheral nerves by analyzing firing rate changes in response to stimulation frequency and amplitude in a feline model.

Statistical Characterization of Cortical-Thalamic Dynamics Evoked by Cortical Stimulation in Mice

This study uses statistical models to analyze neuronal responses to electrical cortical stimulation in mice, achieving high accuracy in stimulus decoding and brain region classification.

NeuroTest: a benchtop testbed for evaluating sensing-capable electrophysiology and neurostimulation systems

NeuroTest evaluates sensing-capable electrophysiology and neurostimulation systems through a low-cost, open-source benchtop platform to standardize testing and reduce variability across institutions.

Focal infrared stimulation modulates somatosensory cortical activity in mice: evidence for TRPV1 ion channel involvement

This study shows that TRPV1 channels are involved in infrared neural stimulation's effect on somatosensory cortical activity in mice.

Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex

This study evaluates the acute biological response to Utah Optrode Array implantation in macaque cortex, identifying design parameters that minimize tissue damage and improve biocompatibility.

Simulation Insights on the Compound Action Potential in Multifascicular Nerves

The paper develops a semi-analytic model to simulate compound action potentials in complex nerves and validates it against in vivo measurements, showing how fascicle activation affects signal shape and magnitude.

High-density extracellular recordings from the interior of intact brain organoids enable automated high-throughput functional assay

This paper develops an automated system to record neural activity from brain organoids and uses it to classify organoids with Alzheimer's disease mutations using a classifier with 100% accuracy.

Extracellular electrophysiological effects on MEA recordings of living mycelium following in-vivo polydopamine polymerisation

The paper investigates the effects of polydopamine polymerisation on extracellular electrophysiology of mycelium, finding significant inhibition at 5 mM and 10 mM concentrations.

Amorphous silicon resistors enable smaller pixels in photovoltaic retinal prosthesis

The paper develops doped amorphous silicon resistors for photovoltaic retinal implants, enabling smaller pixel sizes and improved electric field contrast without reducing photoresponsivity.

PolyGraph - Flexible, Biocompatible & Electrically Optimised Graphene-Polymer Composites for Next-Generation Neural Interfaces

This paper introduces PolyGraph, a biocompatible graphene-polycaprolactone composite with low impedance and high charge injection capacity, demonstrating bidirectional neural interfacing in murine brain slices.

Cortical control of a forelimb prosthesis in mice

This study demonstrates mice controlling a miniature forelimb prosthesis using a brain-machine interface, showing learned movement in 2D and 3D spaces.

A novel hybrid Wireless Integrated Sensing Detector for simultaneous EEG and MRI (WISDEM)

This paper develops a wireless system for simultaneous EEG and fMRI recording, demonstrating its ability to capture neurovascular coupling in the somatosensory cortex.

Electrical stimulation elicits space- and parameter-dependent spiking responses in human cortical organoids

This study shows how electrical stimulation affects spiking responses in human cortical organoids, finding parameter-dependent excitatory and inhibitory responses with local circuit contributions.