Neuroscience and Neural Engineering

Advances in Thin-Film Graphene Neurotechnology for Chronic Nerve Stimulation and Recording

This paper develops a graphene-based electrode with hybrid encapsulation for chronic nerve stimulation and recording, showing improved stability and performance in vivo.

Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings

The paper determines optimal electrode spacing for maximizing single unit yield in neural recordings across species and brain regions.

Optimizing electrode placement and information capacity for local field potentials in cortex

This paper introduces tools to optimize electrode placement and maximize information capacity for local field potentials in the cortex using subject-specific modeling.

Non-mulberry silk fibroin functionalization enhances charge-transfer efficiency in aligned polypyrrole-silk composites for electrically stimulated neurite outgrowth

This paper develops a biohybrid scaffold using functionalized silk fibroin to enhance charge-transfer efficiency, promoting neurite outgrowth in dorsal root ganglion neurons under electrical stimulation.

Multimodal layer-crossing interrogation of brain circuits enabled by microfluidic axialtrodes

This paper introduces a microfluidic axialtrode for multimodal neural interfacing, enabling spatially distributed optogenetics, electrophysiological recording, and drug delivery across brain layers.

Lightweight Adaptive and Recoverable Implants (LARI) for Chronic Single and Dual Neuropixels 2.0 Recordings for Naturalistic Behaviors in Feature-Rich Environments

This paper introduces LARI-1.0 and LARI-mini implants for chronic, high-quality neural recordings in mice during naturalistic behaviors, showing long-term stability and minimal artifacts.

Chronically implantable μLED arrays for optogenetic cortical surface stimulation in mice

This paper introduces a chronically implantable μLED array for optogenetic cortical stimulation in mice, demonstrating long-term stability and effective neuronal responses.

Multimodal optical imaging and modulation through Smart Dura in non-human primates

This paper demonstrates the multimodal capabilities of Smart Dura in non-human primates, enabling high-density electrophysiological recordings and optical imaging with applications in vascular and neural dynamics.

Ultrasound Transparent Neural Interfaces for Multimodal Interaction

This paper develops ultrasound-transparent neural interfaces that enable compatibility with functional ultrasound imaging and therapy, validated through simulations and experiments.

A three-compartment microfluidic platform for investigating signal transmission in the human sensory pathway

This paper develops a three-compartment microfluidic platform to study signal transmission in the human sensory pathway and finds keratinocytes modulate neuronal activity and exhibit low-pass filtering properties.

Carbon Cybernetics Array: a miniaturized carbon-based microelectrode array for intracortical recording

This paper introduces a hermetically sealed carbon-based microelectrode array for neural recording, demonstrating long-term stability and scalability in animal models.

Neuromodulation in neural organoids with shell MEAs

The paper demonstrates neuromodulation in neural organoids using 3D shell MEAs, showing increased neuron firing rates with specific stimulation ranges.

Opto-Myomatrix: μLED integrated microelectrode arrays for optogenetic activation and electrical recording in muscle tissue

This paper introduces Opto-Myomatrix, a device for optogenetic muscle activation and EMG recording, achieving high optical output and low electrode impedance.

Inkube: An all-in-one solution for neuron culturing, electrophysiology, and fluidic exchange

The paper introduces inkube, an open-source system for culturing neurons, electrophysiology, and fluidic exchange, showing that environmental factors like temperature and medium evaporation significantly affect neuronal spiking behavior.

A method for efficient, rapid, and minimally invasive implantation of individual non-functional motes with penetrating subcellular-diameter carbon fiber electrodes into rat cortex

This paper demonstrates a method for implanting wireless neural dust motes with subcellular-diameter electrodes into rat cortex with high success rates and minimal invasiveness.

A neurorecording toolkit for longitudinal assessments of transplanted human cortical organoids in vivo

This paper presents a neurorecording toolkit to longitudinally assess transplanted human cortical organoids in vivo, showing increased neuronal activity and synchronicity over time.

A flexible high-precision photoacoustic retinal prosthesis

This paper presents a photoacoustic retinal prosthesis that stimulates retinal cells with high precision and safety, showing neural modulation in rat models.

Nanoporous Microelectrodes for Neural Electrophysiology Recordings in Organotypic Culture

This paper introduces nanoporous microelectrodes for in situ electrophysiological recordings in organotypic brain slices, demonstrating their viability for three weeks of culture.

A wireless, 60-channel, AI-enabled neurostimulation platform

The paper introduces a wireless neurostimulation device that decodes brain states and delivers closed-loop stimulation in sheep, showing reliable classification of movement and modulation of spectral activity.

Neuronal recordings in head-fixed and freely-moving mole-rats

This paper develops protocols for neuronal recordings in mole-rats, identifies a low-frequency hippocampal theta rhythm, and creates a stereotaxic brain atlas for implantation and histological alignment.

Soft, Transparent and Bioresorbable Microelectrode Array for Transient Electrophysiological Recordings

The paper presents a bioresorbable microelectrode array for transient electrophysiological recordings, validated in cardiac models and applicable to neurological disorders.

Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device

This paper presents a high-bandwidth, wireless brain-computer interface device capable of chronic recordings in animals, demonstrating reliable performance over weeks.

Patterned wireless transcranial optogenetics generates artificial perception

This paper develops a wireless transcranial optogenetic system to generate artificial perceptions in mice through controlled cortical stimulation and demonstrates its effectiveness in operant learning tasks.

Living Neurosheets: Engineering readily deployable neural architectures

The paper introduces Living Neurosheets, modular neural systems that enable scalable, bio-inspired neural architectures with spatial control and multimodal integration.

High-Resolution Spatial Mapping of Electrocorticographic Activities with a 4096-Channel, Multiplexed Flexible Thin-Film Transistor Array

This paper introduces a high-density, flexible ECoG device (NeuroCam) with 4096 channels and 44 sites/mm2 density, validated in a rabbit epilepsy model for high-resolution spatial mapping of neural activity.

Implantable Bioelectronics for Gut Electrophysiology

This paper introduces a bioelectronic implant for recording neural activity in the distal colon of freely-moving rats, demonstrating its ability to capture electrophysiological responses and colonic activity related to food intake and stress.

CUSP: Complex Spike Sorting from Multi-electrode Array Recordings with U-net Sequence-to-Sequence Prediction

CUSP is a deep learning framework for automated detection of complex spikes in neural recordings, achieving expert-level performance and robustness to recording artifacts.

Micro-CT Analysis of a Needle to Nerve Approach for Interfascicular Peripheral Nerve Stimulation in Porcine Nerves

This paper quantifies interfascicular electrode placement in porcine nerves using micro-CT and histology, showing 84% of placements were interfascicular and demonstrating the potential of MiiNS as a selective peripheral nerve interface.

MindSight: A Bio-Inspired Neural Architecture for Visual Restoration via Cortical Electrical Stimulation

This paper introduces MindSight, a deep learning algorithm for cortical electrical stimulation to improve visual restoration, showing better performance in visual perception tasks with macaque monkeys.

Scalable spike sorting across thousands of neurons by modeling neural dynamics with NeuroSort

NeuroSort improves spike sorting by modeling neural dynamics, enabling efficient isolation of thousands of neurons across various recording conditions.