Signaling Pathways in Disease

A novel motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin

The paper identifies a novel composite motif in CLMB that enables multimeric dephosphorylation by calcineurin, influencing its membrane localization and signaling.

NFAT2 drives both Orai3 transcription and protein degradation by harnessing the differences in epigenetic landscape of MARCH8 E3 ligase

This paper shows NFAT2 regulates Orai3 expression differently in non-metastatic and metastatic cancer cells through transcriptional activation and MARCH8-mediated degradation, linked to MARCH8 promoter methylation.

A tethering mechanism underlies Pin1-catalyzed proline cis-trans isomerization at a noncanonical site

This paper identifies a tethering mechanism by which Pin1 catalyzes proline cis-trans isomerization at a noncanonical site in the PPARγ AF-1 domain.

Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted Therapies

This study investigates the differential dynamics and roles of FKBP51 isoforms in response to glucocorticoids using in vitro models and human blood cells, highlighting their distinct functions and implications for targeted therapies.

Human germline biallelic complete NFAT1 deficiency causes the triad of progressive joint contractures, osteochondromas, and susceptibility to B cell malignancy

The paper identifies a human with complete NFAT1 deficiency, revealing its role in joint contractures, osteochondromas, and B cell malignancy through single-cell omic analyses.

Cardiac Gq receptors and calcineurin activation are not required for the hypertrophic response to mechanical left ventricular pressure overload

This study shows that Gq receptors and calcineurin are needed for neurohumoral LVH but not for mechanical TAC-induced LVH, which uses CaMKII-HDAC4-MEF2 pathway.

NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development

The paper identifies NF45/NF90-mediated rDNA transcription as a novel target for immunosuppressants, showing that inhibiting it suppresses T cell activation more effectively than FK506.

Cyclophilins A and B Oppositely Regulate Renal Tubular Epithelial Phenotype

This study shows that Cyclophilins A and B oppositely regulate renal tubular epithelial phenotype through distinct mechanisms involving EMT and fibrosis.

Calcineurin broadly regulates the initiation of skeletal muscle-specific gene expression by binding target promoters and facilitating the interaction of the SWI/SNF chromatin remodeling enzyme

This study identifies four temporal patterns of calcineurin-dependent gene expression during skeletal muscle differentiation and shows Cn promotes gene expression by facilitating chromatin remodeling and transcription factor interactions.