Planarian Biology and Electrostimulation

This study identifies seven heterotrimeric G protein subunits that promote planarian regeneration and two subunits critical for anterior polarity re-establishment, while also finding five G proteins modulate behavior.

The paper identifies FoxG as an upstream regulator of wnt1 involved in posterior identity specification during planarian regeneration through genomic analyses.

The paper proposes a conceptual and computational framework for regeneration of form and function in biological organisms, demonstrating its ability to restore anatomical and bioelectric homeostasis in an in silico model.

The paper shows that nail tissue, not dorsoventral polarity, is essential for digit tip regeneration, and identifies Lmx1b's role in this process through transcriptomic analysis.

This study shows that brain hormones, specifically methylfarnesoate, are essential for posterior regeneration in Platynereis dumerilii, and their absence after decapitation impairs regeneration.

The paper shows that regenerated crustacean legs in Parhyale precisely replicate the microanatomy, sensory function, and transcriptional profiles of uninjured legs.

The paper identifies enhancer-like elements in planarian adult stem cells using epigenetic and expression data, and links them to regulatory networks involved in regeneration.

This study shows that Klf4 is essential for germline and yolk cell development and regeneration from somatic stem cells in planarians.

This study identifies two intestine-enriched apolipoprotein b orthologs in planarians that are essential for stem cell differentiation and regeneration by transporting lipids to target tissues.

This study compares gene expression dynamics during leg development and regeneration in Parhyale hawaiensis, finding distinct temporal patterns despite shared gene sets.

This paper characterizes a new planarian isolate, Girardia sp. (Guanajuato), at morphological, cellular, and molecular levels to identify unique traits and facilitate future comparisons.

Electric stimulation restores DNA integrity and cell cycle in planarian tissues damaged by ionizing radiation through Ca2+ signaling and stem cell activation.

This study identifies Src-1 as a factor that promotes robustness in planarian anteroposterior axis patterning by restricting head and trunk identities to anterior positions.

The paper identifies Tig1 as a regulator of proximo-distal identity during salamander limb regeneration through single-cell RNAseq analysis.

The paper identifies genes and factors involved in female germ cell development and regeneration in planarians, revealing shared molecular signatures with pluripotent stem cells and distinct somatic roles.

This study shows that the Xenopus laevis tadpole microbiome and lipopolysaccharide signaling influence tail regeneration outcomes, with TLR4 playing a partial role.

The paper identifies critical RING/U-box E3 ubiquitin ligases involved in planarian tissue regeneration through RNAi screening and functional analysis.

The paper shows that cell cycle arrest is necessary for stem cell differentiation in planarians, as inhibiting Cdh1 disrupts tissue homeostasis and regeneration.

This study identifies Hox gene functions in adult tissue segmentation and asexual reproduction in planarians, showing distinct roles for hox3 and post2b.

This study identifies that limb nerves provide essential cues for regulating the final size of regenerating axolotl limbs during the 'tiny-limb' stage.

This paper develops a transgenesis protocol for Hofstenia miamia, enabling stable transgene integration and tissue-specific fluorescent expression, revealing new insights into regeneration and cell biology.

The paper shows that bacteria are necessary for initiating tadpole tail regeneration by activating TLR pathways and sustaining NF-κB activity, which drives ROS production and regeneration.

This study identifies TRiC's role in maintaining stem cell function during planarian starvation by activating the UPR and regulating energy and lipid metabolism.

This paper develops a mathematical model to explain planarian regeneration by incorporating positional control genes and wnt-related signaling gradients, showing improved polarity preservation in regeneration.

This study shows planarian stem cells adjust their behavior based on missing tissue type, with pharynx regeneration requiring specific proliferation and ERK signaling, while eye regeneration does not.

The paper identifies extrinsic cues from chondrogenic progression that inhibit AER cell formation and limit limb regeneration in Xenopus tadpoles.

This study shows apoptosis and Wnt signaling are required for regeneration and homeostatic growth in Ciona, with apoptosis promoting progenitor cell survival.

This study identifies and functionally characterizes five CBP genes in planarians, showing their roles in stem cell maintenance and differentiation.

The paper identifies two planarian CBP family members, CBP2 and CBP3, with distinct roles in stem cell maintenance and function.