Heterotopic Ossification and Related Conditions

Pathogenic transcriptional reprogramming of fibro-adipogenic progenitors in mice with FOP and its mitigation by inhibition of ACVR1 and activin A

This study identifies early transcriptional changes in fibro-adipogenic progenitors in FOP mice and shows that inhibiting ACVR1 or activin A can mitigate these changes.

Aberrant ciliogenesis induced by enhanced BMP signaling causes heterotopic ossification

This paper identifies BMP signaling as a driver of heterotopic ossification by promoting ciliogenesis and establishing a sensitized signaling hub that facilitates osteochondrogenic differentiation.

Gut microbiome-dependent IL-1 signaling is a mediator of ACVR1R206H-driven heterotopic ossification

Antibiotic disruption of the gut microbiome reduces heterotopic ossification in FOP mice via an IL-1 mediated pathway.

Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification

This study identifies rosiglitazone, a PPARγ agonist, as a potential therapy for fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification by converting ectopic bone to fat.

Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva

The paper uses multi-omics analyses to identify signaling dysregulation in FOP, highlighting AP-1 as a novel therapeutic target.

A gene co-expression network-based analysis of mesenchymal stromal cells reveals novel genes and molecular pathways underlying heterotopic ossification

The paper identifies HO-related gene modules and hub genes using WGCNA and PPI networks, revealing pathways involved in stem cell pluripotency and immune responses.

Genome-wide association and functional analyses identify CASC20 and KIF26B as target loci in heterotopic ossification

This study identifies CASC20 and KIF26B as genetic loci associated with heterotopic ossification through genome-wide association and functional analyses.