Heterotopic Ossification and Related Conditions

A closed-loop cell therapy engineered to autonomously secrete Activin A inhibitor protects from fibrodysplasia ossificans progressiva

This paper develops a closed-loop cell therapy that secretes an Activin A inhibitor to prevent heterotopic bone formation in a mouse model of FOP.

Hyperactive BMP and Mechanosignaling Remodel Chromatin to Drive Aberrant Osteogenesis in FOP

This study shows that the Acvr1R206H mutation in FOP remodels chromatin through BMP-SMAD and Rho/ROCK signaling, driving aberrant osteogenesis, and identifies reversible chromatin changes as a therapeutic target.

MEST inhibits ciliary sphingomyelin synthesis to promote tendon stem/progenitor cells osteochondrogenesis in traumatic heterotopic ossification

This study identifies MEST's role in promoting tHO by inhibiting ciliary sphingomyelin synthesis and enhancing Hh signaling in TSPCs.

The role of muscle fascia in heterotopic ossification and maintenance of skeletal muscle integrity in fibrodysplasia ossificans progressiva

This study shows that fascial injury, not direct muscle injury, induces heterotopic ossification in FOP by activating Acvr1R206H-expressing fibro-adipogenic progenitors, leading to muscle destruction and impaired regeneration.

PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

This study confirms that PI3K inhibition with BYL719 prevents heterotopic ossification by blocking osteochondroprogenitor specification and reducing inflammation.

Hair follicle-resident progenitor cells are a major cellular contributor to heterotopic subcutaneous ossifications in a mouse model of Albright hereditary osteodystrophy

This study identifies hair follicle-resident progenitor cells as a major contributor to heterotopic subcutaneous ossifications in AHO mice and shows SFRP2 upregulation and its role in SCO development.

Genetic regulation of injury induced heterotopic ossification in adult zebrafish

This study develops a zebrafish injury model to study heterotopic ossification, identifies differentially regulated genes, and shows that Kcnk5b and Il11ra influence bone formation after injury.

Reduced GS domain serine/threonine requirements of Fibrodysplasia Ossificans Progressiva mutant type I BMP receptor ACVR1 in the zebrafish

This study investigates how FOP mutant ACVR1 receptors in zebrafish have altered requirements for GS domain phosphorylation and signaling, revealing distinct mechanisms for ligand-dependent and -independent signaling.

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro/adipogenic progenitors in fibrodysplasia ossificans progressiva mice

This study shows that an anti-ACVR1 antibody worsens heterotopic ossification in FOP mouse models by altering fibro/adipogenic progenitor behavior.

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

The paper identifies saracatinib as a potent ALK2 inhibitor effective in preventing heterotopic ossification in FOP models.

Over-expression of wild-type ACVR1 in fibrodysplasia ossificans progressiva mice rescues perinatal lethality and inhibits heterotopic ossification

This study shows that over-expressing wild-type ACVR1 in FOP mice reduces heterotopic ossification and rescues perinatal lethality.