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The paper uses clickable protein tags to study α-synuclein aggregation in yeast, revealing membrane interactions drive aggregation and identifying key residues that influence this process.

This paper identifies a novel bacteriophage endolysin LysPH with broad antibacterial activity and elucidates its structural basis for substrate recognition and catalytic activation.

This paper investigates the structural impact of glycosylation on the β3-subunit of voltage-gated sodium channels using glycan profiling and molecular dynamics simulations.

This study examines how apoA-I dissociation from HDL affects ABCA1-mediated cholesterol efflux in CAD patients and controls, finding altered correlations with gene expression and lipid ratios.

This paper reveals the structural basis of NSD2 degradation via SCF-FBXO22 recruitment, showing how aldehyde-based degraders induce conformational changes for covalent binding and efficient protein degradation.

This paper introduces a multi-magnification cryo-ET technique that combines low- and high-resolution data to study cellular structures across scales.

The paper identifies a novel luciferase gene, CRLuc, from a previously unidentified firefly species using DNA extraction and bioinformatic analysis.

This study identifies how hydrogen-bonding changes in OXA-48 variants affect imipenem hydrolysis efficiency and resistance.

This paper investigates ZDHHC13, a non-canonical S-acyltransferase, and finds it may function as a pseudoenzyme by facilitating S-acylation through interactions with other PATs.

This study investigates the biochemical functions of the MB domain of CARMIL, showing it targets proteins to membranes, activates CP, and enhances actin assembly.

The paper uses experimental results from de novo protein designs to identify and resolve failure modes in the Rosetta energy function, improving its accuracy in predicting stable protein structures.

This study evaluates risperidone's subacute effects on oxidative metabolism in rat brain and liver tissues, finding dose-dependent changes in antioxidant enzyme activity and lipid peroxidation.

This study investigates how the R39C mutation in sialin affects its lysosomal transport function by analyzing structural and dynamic changes in the protein.

This study characterizes conkazal-M1, a conotoxin from Conus magus, showing it acts as both a protease inhibitor and a neuroactive peptide.

The paper presents cryo-EM structures of prothrombinase complexed with prothrombin and meizothrombin, revealing substrate allostery as the mechanism for processive cleavage.

The paper identifies a novel ubiquitin-binding groove on the yeast 26S proteasome using photo-crosslinking mass spectrometry.

This study investigates the role of ADA2 in yeast, showing it regulates triterpene metabolism, phospholipid homeostasis, and autophagy through interactions with TORC1 and the Pah1 pathway.

This study shows oxidative stress reduces DUB activity in aging brains, which can be reversed with antioxidants, suggesting a reversible cause of proteostasis decline.

This study shows PARP1 prevents TOP1 from causing deletions at STRs by inhibiting TOP1-DNA adduct formation, which could inform therapies for cancers with RNase H2 mutations.

The paper investigates how chaperones like Hsp70, Hsp90, and TRiC bind to nascent p53 during translation, showing TRiC's specificity and how mutations affect this process.