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This paper develops a nanovial-based platform to identify functional TCRs from unconventional T cells, isolating and validating five novel MAIT TCRs with antigen-specific activity.

This paper introduces 3D-RIM, a method that achieves super-resolved volume imaging of thick live specimens with high contrast and resolution across multiple microns.

This study evaluates a vitamin C-loaded hyaluronic acid/collagen scaffold for enhanced wound healing in rat models, showing improved fibroblast activity and reduced inflammation.

This paper develops an RNA base editor using CRISPR-Cas13 and ADAR2DD to correct mutations in inherited retinal diseases, showing up to 60% editing efficiency in vitro and partial rescue in mouse models.

This study uses pulsed speckle contrast optical spectroscopy to detect microclots in biofluids, showing decreased speckle contrast with increasing microclot concentration.

The paper shows that increasing proteasomal activity improves secreted protein production in ER-stressed cells, while autophagy inhibition also enhances secretion.

This study shows that cyclic mechanical loading disrupts cytoskeletal symmetry in 3D scaffolds by combining matrix strain and fluid shear stress.

This paper introduces an automated framework for optimizing MRI RF coil design to improve SNR performance using full-wave electromagnetic simulations and ultimate SNR benchmarks.

This paper introduces a superresolution microscopy technique called centroid reassignment microscopy (CRM) that enables fast, robust, and protocol-compatible imaging of live samples.

This study develops and characterizes AVA, single-domain protein binders that neutralize major household allergens from cats, dogs, and dust mites.

This study shows that functionalizing DNA nanodevices with growth-factor ligands improves their cellular and in vivo uptake and effectiveness.

This study uses long-read sequencing to analyze genomic and transcriptomic changes in AAV-CRISPR therapy for DMD, revealing complex editing outcomes and developing new methods for detection.

This paper develops a standardized, cost-effective microfluidic LNP synthesis protocol with reproducible results across user groups and lipid types.

This paper introduces MAPA, a high-throughput platform for discovering and optimizing aptamer beacons for molecular targets, demonstrating its effectiveness for glucose, serotonin, and dopamine.

This paper demonstrates that 3D-printed scaffolds encapsulating red blood cell-derived extracellular vesicles can deliver sncRNAs effectively for CNS therapy.

This paper develops a single AAV vector system for liver-targeted gene knock-in therapy in mouse models of inherited liver diseases, achieving efficient therapeutic gene insertion without germline transmission.

The paper determines the interaction affinity and kinetics of the Aos1-Uba2 heterodimer during SUMO activation using qFRET and SPR, showing increased stability with SUMO and ATP binding.

This study couples microbial electrolysis cells with microbial fuel cells to produce green hydrogen using farm soil, wastewater, anaerobic sludge, and cow dung, achieving an average hydrogen production rate of 6.9 mL/day.

The paper presents a low-cost spinning disk confocal microscopy system using a 25 megapixel CMOS camera and custom hardware, validated with biological samples.

This study proposes optimized dry EEG electrode tip geometries to reduce mechanical stress on the scalp under tilted conditions using finite element analysis.