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Targeted measurement of blood flow in the Anterior Cerebral Artery using Diffuse Correlation Spectroscopy

This paper demonstrates a method to measure blood flow in the Anterior Cerebral Artery using Diffuse Correlation Spectroscopy with optimized probe geometry and placement.

Cryoaerosolization Enables Scalable Vitrification-Based Cell Cryopreservation

This paper introduces a cryoaerosolization method for scalable vitrification-based cell cryopreservation, achieving high cooling and warming rates with high throughput and cell viability.

A generalizable speech neuroprosthesis

This paper introduces a multi-user transformer-based decoder for intracortical speech BCIs, achieving lower word error rates with less training data than individual models.

Robust Regularization Enables Automated, Real-Time Square-Wave Voltammetry Signal Quantification

This paper introduces ASWIFT, a tool for automated SWV signal quantification that outperforms existing methods in simulated and in vivo settings.

Cerclage Wire as an Affordable Alternative for Internal Fixation in Murine Critical Sized Defect Models

This study demonstrates that cerclage wires can be used in a murine critical sized defect model to achieve affordable and clinically relevant internal fixation.

The Mechanical and Biological Evolution of Pressure Ulcer Formation and Healing in Mice

This study investigates the mechanical and biological changes in mouse pressure ulcers over time, showing how tissue deformation, inflammation, and collagen remodeling co-evolve during ulcer formation and healing.

Negligible incorporation of lipophilic dyes into bona fide small extracellular vesicles

The study shows lipophilic dyes poorly label bona fide small extracellular vesicles, questioning their reliability for EV tracking.

Three-Dimensional Photoacoustic Tomography with Ultrasound Localization Priors

This paper introduces 3D-PAULMprior, a method that improves 3D photoacoustic tomography by integrating ultrasound localization priors, enhancing resolution and accuracy in vascular imaging and oxygen saturation estimation.

TAXISCAN, Optimizing throughput and behavioral depth in standard C. elegans chemotaxis assays

TAXISCAN improves chemotaxis assay throughput and behavioral depth in C. elegans by automating image acquisition and analysis.

Targeting Ligand Shape While Preserving a Warhead through Guided Diffusion and Adaptive Staged Growth

This paper improves molecular growth models by using shape guidance and adaptive growth to connect fragments while preserving a warhead.

Integrated Bioinformatics Analysis Reveals Candidate Hub Genes and Regulatory Networks Associated with Preeclampsia

This study identifies candidate hub genes and regulatory networks associated with preeclampsia using bioinformatics analysis of placental transcriptomic data.

Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork

The paper compares transcriptomic differences between high and low flow regions in mouse and human trabecular meshwork to understand intraocular pressure regulation.

Machine Learning-Assisted Evolution of Broadly Functional Enzyme Libraries

This paper uses machine learning to guide the creation of enzyme libraries with broader catalytic activity, showing improved performance across multiple reactions.

Material Composition and Implantation Site Affect in vivo Device Degradation Rate

This study investigates how material composition and implantation site affect in vivo degradation rates of tissue engineering devices using CT-visible radiopaque composites.

Bioengineering of a Chimeric Metarhizium anisopliae cPr1A Protease with Enhanced Binding and Enzyme Activity Through C-terminal Fusion of Bombyx mori Chitin-Binding Domain

This paper engineers a chimeric protease by fusing a chitin-binding domain to enhance cuticle binding and protease activity in Metarhizium anisopliae.

Small-scale bioreactor cultivation of HEK293-based suspension cells increases extracellular vesicle yield

This study compares EV yield from HEK293 cells in shaker flasks and bioreactors, finding a 3-fold increase in EV yield with bioreactors.

A Microgel-Based Platform for Tunable Expansion and Function of γδ T-cells

This paper develops a microgel platform to enhance γδ T-cell expansion and function while preserving cytotoxicity and donor-specific responses.

Glycocalyx-Directed Enzymatic Hydrogels Unlocks Fibroblast Regeneration to Promote Diabetic Wound Healing

This paper develops glycocalyx-targeting hydrogels that enhance fibroblast regeneration in diabetic wounds by reversing pathological glycocalyx thickening and improving wound closure.

An open-source application for applying rapid transient perturbations using a split-belt treadmill

This paper describes an open-source method for inducing slip- and trip-like perturbations using a split-belt treadmill, validated for accuracy and stability measurement in individuals with limb loss.

Viscoelastic Niches Shape γδ T-Cell Phenotype and Effector Function

This study shows that matrix viscoelasticity influences γδ T-cell phenotype and function, with slow-relaxing matrices enhancing cytotoxic programs and tumor control.