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The paper models outer hair cells as coupled oscillators to show how they overcome impedance mismatch and amplify basilar membrane motion, supporting the cochlea's high-frequency performance.

The paper identifies amyloid fibril structures of CHCHD10 and links them to neurodegeneration, showing sequence differences between CHCHD10 and CHCHD2 allow co-aggregation.

This paper introduces MSA Pairformer, a memory-efficient protein language model that outperforms existing methods in contact prediction and variant effect prediction.

This study investigates how body oscillations in silkmoths reduce aerodynamic power requirements by altering wing rotation relative to airflow during flight.

This paper introduces a method using charged polymer-encapsulated nanodiscs and FCS to purify fluorescently labeled membrane proteins in native-like lipid environments, avoiding aggregation and enabling structural studies.

The paper uses cryo-EM to identify an early intermediate state in dynein activation by LIS1, termed Pre-Chi, and shows its functional importance through mutational analysis.

This study develops a coarse-grained MD model to study polyQ aggregation mechanisms and finds that longer sequences aggregate faster and amyloid growth occurs primarily in the β-sheet direction.

This study demonstrates the use of O-PTIR spectroscopy for label-free detection of micro- and nanoparticles in tissues, showing superior resolution and signal quality compared to FTIR.

The paper shows Nde1 enhances Lis1 binding to autoinhibited dynein, facilitating Phi conformation opening through a novel intermediate state.

The paper develops a theory to predict chromatin dynamics using static 3D structures, showing that fast enhancer-promoter dynamics and scaling relationships are determined by chromatin organization.

This study presents cryo-EM structures of human rho1 GABAA receptors bound to antagonist and agonist drugs, revealing distinct binding poses and conformational changes that explain their pharmacological effects.

The paper characterizes the multi-timescale structural dynamics of the p53 transactivation domain using NMR and simulations, revealing a hierarchical energy landscape.

This paper combines geometric pocket detection with large language models to prioritize protein binding pockets for drug discovery, using a curated dataset and automated pipeline.

The paper investigates how peripheral heterochromatin tethering influences nuclear mechanical response through simulations and experiments.

This study identifies and quantifies drug-free lipid nanoparticles in mRNA-LNPs using SANS and nano flow cytometry, leading to more accurate structural models.

This study investigates how reconstituted Pdr5 transporter moves Rhodamine 6G across a lipid bilayer using ATP, showing active transport of the cation.

This study investigates Yohimbine's interaction with hairpin-duplex oligonucleotides using spectroscopic and computational methods, revealing groove-binding and thermodynamic properties.

This paper identifies a shared interface for EphA2-ephrin-A1 cis and trans interactions, showing cis interactions inhibit trans signaling and contribute to oncogenesis.

NEXT-FRET identifies protein folding intermediates under native conditions using a solution-based smFRET platform with a time-variant Gaussian Mixture Model.

This study uses simulations to show how small-molecule cosolutes alter condensate morphology by changing interaction strengths and stoichiometry.