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This study uses numerical simulations and analytical theory to examine the physical requirements and biological consequences of asymmetric hop diffusion in cell membranes.

This study uses DNP-assisted NMR to show that α-synuclein adopts helical-rich conformations near the cell periphery in intact cells.

This study investigates how yeast condensin affects the rheology and viscoelasticity of entangled DNA, showing it increases viscosity and elasticity even without ATP.

This study determines the cryo-EM structures of URAT1 with inhibitors and reveals their binding mechanisms and conformational changes.

This paper improves EPR sensitivity for small aqueous biological samples using optimized dielectric resonators and multi-channel cells.

This study shows nanoscale membrane curvature and nuclear deformation regulate mechanotransduction by modulating YAP/TAZ nuclear localization through biophysical modeling and experiments.

The paper introduces an all-optical Diamond Heater-Thermometer to enable precise thermal modulation of ion channels in living cells.

This study infers VEGFR2 dimerization kinetics on live cell surfaces using single-molecule imaging and mathematical modeling, revealing differences between full-length and truncated variants.

The paper develops a method for in situ genotyping of bacterial libraries using chromosomally expressed barcodes to measure intracellular maturation times of red fluorescent proteins.

This paper uses DNA origami to create a nanoscale metastructure that can switch between frustrated and non-frustrated mechanical states, with distinct free energy profiles.

This study identifies a salt bridge in the bacterial ion channel SthK that functions as a temperature sensor, with lipid composition modulating its sensitivity to temperature changes.

This study investigates how DNA partitioning affects the phase behavior and dynamics of FUS condensates, revealing its role in modulating liquid-to-solid transitions and microstructure over time.

This paper characterizes the optimal strategy for amendable decisions in living systems and shows they can be made with zero error probability in finite time.

The paper uses single-cell imaging to show phenotypic sorting and bet-hedging in Vibrio cholerae biofilms through c-di-GMP level differences.

This study investigates how matrix stiffness influences spheroid invasion, collagen remodeling, and stress propagation in the ECM using 3D spheroids and stress sensors.

This paper introduces HELM, a hybrid clustering method combining k-means efficiency with hierarchical flexibility, and demonstrates its application to protein-DNA and protein folding simulations.

This paper investigates thermally activated irreversible homogenization of G-quadruplexes in C9ORF72 hexanucleotide repeats, linking conformational changes to disease mechanisms.

This study shows FABP4 binds diverse PFAS with varying affinities and identifies three distinct binding modes through crystal structures.

This study identifies a histidine switch in C9CARD that regulates pH-dependent filament formation through electrostatic interactions and structural changes.

This study shows how modifying anchor points on Anticalin scaffolds improves binding strength and adhesion to CTLA-4 under shear stress, enhancing targeted drug delivery.