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This study identifies a genomic region associated with microconidia production in Pyricularia oryzae using GWAS, suggesting potential genes involved in male fertility.

This paper introduces LIT, a method to detect latent genetic interactions using multiple traits, showing improved power compared to univariate methods in obesity-related traits.

This study shows that ACTN3 genotype affects androgen response in skeletal muscle by altering AR expression and pathways related to muscle homeostasis.

This study identifies hyperactivation of innate immune signaling as a consequence of SMN depletion in Drosophila SMA models, revealing a conserved regulatory role of the SMN complex.

This study shows RPA is essential for maintaining the meiotic recombination checkpoint in yeast by sensing ssDNA and activating Mek1 kinase to regulate pachytene exit.

The paper investigates how Polycomb Response Elements (PREs) function in the ON transcriptional state, showing that PREs can still loop and interact with enhancers while some PcG proteins remain bound.

The paper identifies nuclear envelope homeostasis as critical for resolving telomere entanglements in fission yeast through genetic screens and functional analysis.

This study identifies a physical interaction between Dmc1 and Mlh1-Mlh3 in yeast meiosis and shows that Dmc1 promotes crossover resolution by recruiting Mlh1-Mlh3.

This study identifies the role of Ranbp2's cyclophilin domain in regulating crystallin proteostasis and neuroprotection in the chorioretina through proteomic analysis of genetically modified mice.

The paper investigates the effects of PACS1 and PACS2 variants on protein localization in C. elegans, showing altered localization and functional conservation with human proteins.

This study identifies a single mutation G454A in CYP9K1 as a driver of pyrethroid resistance in Anopheles funestus, reducing bed net efficacy and highlighting the need for resistance monitoring.

The paper introduces Haplotype Function Score (HFS) to improve genetic association analysis and polygenic prediction by replacing genotypes with functional scores, showing increased causal findings and better cross-ancestry prediction.

The paper identifies a Niemann-Pick type C mouse model with accelerated brain aging as a novel model for Alzheimer's disease research by analyzing transcriptomic data from congenital diseases.

This study shows that a myosin ATPase inhibitor reverses HCM phenotypes in pediatric iPSC-cardiomyocytes, with effects dependent on the underlying genetic variant.

This study shows that SI gene variants affect sucrose intake and preference in mice and humans, linking SI dysfunction to reduced consumption and disliking of sucrose-rich foods.

The paper creates a zebrafish model of CMT4B3 that mirrors human disease features, providing a pre-clinical tool for research and therapy development.

The paper assesses transcriptional variability in hiPSC-derived cardiomyocytes from donors with left ventricular hypertrophy, distinguishing technical from biological variability and identifying 'noise' and 'signal' genes.

This study identifies Smpd1's role in tracheal gas-filling in Drosophila embryos by regulating ceramide-specific chitin-clearance, showing that lipid metabolism defects contribute to respiratory dysfunction.

CoVar identifies coordinated regulators driving gene expression changes by analyzing network connectivity in perturbed data, revealing key genes missed by differential expression alone.

The paper investigates how uncertainty in honeybee mating strategies affects genetic parameter estimates and proposes methods to correct biases in genetic evaluations.