Discover, rate, and discuss biology preprints.

The paper identifies a conserved arginine residue in the Dam1 complex subunit Dad2 that is essential for viability in yeast but less so in fungi with regional centromeres, suggesting functional plasticity in chromosome-microtubule coupling.

This study introduces dicistrovirus IRESs into UAS/SV40-polyA constructs in Drosophila, leading to premature polyadenylation and enhanced overexpression of upstream ORFs.

The paper uses deep learning to analyze chromatin accessibility and gene expression during reprogramming, revealing how TF concentrations and motif syntax influence cis-regulatory networks.

The paper shows that ADAR1p150 prevents MDA5 and PKR activation through distinct mechanisms, preventing fatal autoinflammation.

The paper uses phenomics and machine learning to predict protein functions in fission yeast, identifying novel roles and validating predictions through experimental validation.

The paper examines metabolic and molecular changes in Sorex araneus during seasonal shrinkage, identifying shifts in oxidative phosphorylation, fatty acid metabolism, and FOXO signaling.

The paper investigates DUP-TRP/INV-DUP genomic rearrangements in neurodevelopmental disorders, identifying four SV haplotypes and refining template switching points using multiple sequencing technologies.

This paper compares methods for estimating GWAS heritability using summary statistics, proposing a PRS-based method that outperforms SLR but underperforms LMM in real data.

This paper demonstrates that hydroxymethyl-γ PNA oligomers enhance gene modification in mouse bone marrow cells compared to diethylene glycol-γ PNA.

This paper develops an indel-based genetic map for hazelnut hybrids to improve breeding efficiency using next-generation sequencing.

This study identifies three distinct pathways by which glucose metabolism activates TORC1 in yeast, including both Rag GTPase-dependent and independent mechanisms.

The paper quantifies mutation and selection impacts on rDNA copy number variation in yeast, finding high mutational variance and stabilizing selection.

The paper uses structural equation modeling on UK Biobank data to investigate the genetic basis of neuroticism, finding that significant variants are associated with brain-expressed genes and fear-related behaviors in mice.

This study identifies dicer-like3 as essential for paramutation in Zea mays, showing its role in maintaining repression at specific loci despite minimal changes in DNA methylation.

The paper investigates dominance and additivity in mammalian genetics, finding dominance accounts for 25% of heritable variance and reveals novel dominance QTLs and trans-acting effects in gene expression.

This study maps quantitative trait loci (QTL) for osmotic stress response in Zymoseptoria tritici, identifying candidate genes and QTL associated with salt tolerance.

The paper uses CRISPR-Cas9 in mice to identify modifier genes that affect the severity of tyrosinemia type 1 by editing enzymes in the tyrosine catabolic pathway.

This study shows that mutating lysine-36 of Drosophila histone H3.3 reduces adult lifespan and disrupts genomic and transcriptomic stability.

This study investigates how MBNL proteins and RNA decay pathways regulate mutant DMPK mRNA in DM1, showing that their absence reduces RNA foci and promotes mRNA degradation.

The paper identifies shifts in isoform usage in Tregs associated with Type 1 Diabetes by comparing gene expression between cases and controls.