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Varied forms of mutant tRNA mistranslation produce distinct phenotypes across multiple model organisms

This study investigates how different tRNA mutations lead to varied toxic phenotypes across organisms, finding that amino acid property changes and mistranslation frequency are key factors.

Phenotypic plasticity, stalk geometry, and noncoding variation underpin stalk lodging resistance in maize

This study identifies genetic and phenotypic factors contributing to stalk lodging resistance in maize by analyzing intermediate traits and their genetic correlations.

Dynamic neuro-immune regulation of psychiatric risk loci in human neurons

The paper investigates how maternal and fetal immune activation interacts with genetic risk profiles to influence neuronal regulatory activity and psychiatric traits.

Harnessing Vitis germplasm diversity to dissect and predict adventitious rooting traits in grapevine

This study evaluates Vitis germplasm diversity to predict adventitious rooting traits, identifying genetic loci and developing genomic prediction models for improved grapevine rootstock breeding.

Genetic variation in behavioral and physiological responses to copper in Drosophila melanogaster

The paper investigates genetic variation in copper resistance traits in Drosophila melanogaster, finding distinct genetic architectures for feeding avoidance, oviposition avoidance, and physiological tolerance.

The stress-induced transcription factor ATF4 has multiple conserved retrocopies that can alter gene expression

This study identifies and characterizes conserved ATF4 retrocopies in primates that are functionally active and influence ISR signaling.

A multi-tissue epigenomic atlas links the sheep non-coding genome to domestication and complex traits

SheepEpimap combines 516 histone CUT&Tag, ATAC-seq and RNA-seq datasets from 43 sheep tissues to annotate 2.93 million cis-regulatory elements and 145,407 allele-specific variants for trait interpretation.

Estimating the correlation of exchangeable variables in assortative mating

This paper introduces CorSym, an unbiased estimator for Pearson correlation in exchangeable variable pairs, demonstrating its effectiveness in reducing order bias in assortative mating studies.

MANF Clears Mutant Uromodulin in Human Kidney Organoids of Autosomal Dominant Tubulointerstitial Kidney Disease

This study shows MANF reduces mutant uromodulin in kidney organoids by enhancing autophagy through IP3R1 repression, suggesting potential for treating ADTKD and similar protein misfolding diseases.

Causal inference for multiple risk factors and diseases from genomics data

The paper introduces CI-GWAS, a method to improve causal inference in GWAS by addressing confounding and pleiotropy, finding few suitable IVs and replicating some but not all previously reported causal links.

A genomewide association study for bristle number variation in Drosophila melanogaster

The paper performs a GWAS on bristle number variation in Drosophila melanogaster, identifying significant genomic regions and candidate genes associated with abdominal and sternopleural bristle numbers.

optix regulates abdominal melanin pigmentation in the tobacco hawkmoth Manduca sexta

This study disrupts optix in Manduca sexta and finds it regulates abdominal pigmentation, replacing orange with black eumelanin, suggesting optix modulates an alternative pigment pathway.

Ciliary ARL13B drives renal cystogenesis via its GEF activity

This study identifies ciliary ARL13B's GEF activity as a driver of Pkd1-dependent renal cystogenesis in mice.

A haploid wild yeast resource for exploring the natural ecology of Saccharomyces cerevisiae

This paper establishes a haploid yeast strain collection to study ecological and reproductive divergence in wild S. cerevisiae, finding that structural genomic variation and metabolic gene divergence drive these traits.

Next-generation insect digitization: combining phenomics and genomics by subsequent synchrotron X-ray imaging and DNA sequencing

The paper demonstrates that high-quality DNA and high-resolution 3D tomograms can be obtained from the same insect specimens by optimizing irradiation conditions and prioritizing rapid scanning before DNA extraction.

Multiplexed Quantification of Variant Abundance in the Globin Gene Family: Integrating Saturation Mutagenesis with Cross-Paralog Prediction

The paper presents a hybrid experimental and computational framework to quantify variant abundance in globin genes, using saturation mutagenesis and deep learning for cross-paralog prediction.

Genome sequencing reveals novel pathogenic deep-intronic PCDH15 variants, amenable to antisense oligonucleotide-based splice correction

The paper identifies two novel deep-intronic PCDH15 variants in Usher syndrome patients and demonstrates the efficacy of antisense oligonucleotides in correcting their splicing defects.

Genetic and Behavioral Variation Underlying an Integrated Temporal Phenotype in an Admixed South American Population

The paper investigates genetic and behavioral factors influencing chronotype in an admixed Uruguayan population, identifying PER2 and BTRC as key genes associated with circadian rhythms.

u4atac regulates cilium biogenesis through splicing of the minor intron of tmem107l and rfx7b in zebrafish developing brain

The paper identifies TMEM107 and RFX7 as key genes regulated by U4atac that contribute to ciliary defects and brain development issues in zebrafish.

OPTIMIZING PRE-PROCESSING OF NEAR INFRARED SPECTRA FOR PHENOMIC PREDICTION USING SINGULAR VALUE DECOMPOSITION

This paper proposes using singular value decomposition in near infrared spectroscopy pre-processing for phenomic prediction, showing it performs as well as classical chemometrics methods with less parameter optimization.