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Environmental DNA monitoring of waterfowl reveals community changes during migration

This study evaluates environmental DNA (eDNA) as a tool for monitoring waterfowl communities during migration, showing it can detect species composition and relative abundance but not absolute numbers.

CRISPR activation of PIKFYVE as potential therapy for FIG4 deficiency

This study uses CRISPR activation to upregulate PIKFYVE in Fig4 deficient mice, showing that a 2-fold increase is insufficient to rescue lysosomal enlargement and survival.

Exposure of Men to PTSD-Promoting Trauma Elevates Levels of Sperm miRNAs with Anxiety and Depression-Inducing Activities

This study finds that men exposed to trauma have elevated sperm miRNAs linked to anxiety and depression in offspring, though not all trauma-exposed men show increased anxiety or depression themselves.

X chromosome association analyses using multiple models identifies 18 genetic loci influencing dietary intake in UK Biobank

This paper identifies 18 novel X chromosome loci associated with dietary intake traits using multiple X-WAS models in the UK Biobank.

Phosphatidylinositol Transfer Protein-1 Integrates Insulin/IGF-1 and TOR Signaling to Negatively Regulate Lifespan and Healthspan in Caenorhabditis elegans

This study identifies pitp-1 as a regulator of healthy aging in C. elegans that integrates insulin/IGF-1 and TOR signaling to influence lifespan and healthspan.

Increased replication-associated single-stranded DNA promotes formaldehyde-induced mutagenesis.

This study shows that replication-associated single-stranded DNA increases formaldehyde-induced mutagenesis through specific repair pathways.

ELP1 Gene Augmentation Restores Visual Function in a Mouse Model of Familial Dysautonomia

This study shows that gene supplementation with ELP1 in a mouse model of familial dysautonomia rescues retinal structure and function, suggesting it as a potential therapy for FD-associated optic neuropathy.

Prevalence, distribution, and mechanisms of genetic dominance in the yeast mating pathway

The paper quantifies dominant and recessive mutation rates in yeast mating pathway mutants and identifies genes associated with dominance.

Massively parallel reporter assays for CYP3A4 enhancer variants alongside their native promoter

The paper uses a modified MPRA to assess CYP3A4 enhancer variants with their native promoter, identifying variants with significant regulatory impact on drug response and cancer severity.

The yeast mitochondrial Porin represses Snf1/AMP Kinase signaling to attenuate viral replication

The paper identifies Por1 as a mitochondrial protein that represses Snf1/AMP Kinase signaling to limit L-A mycovirus replication in yeast.

SNPic: SNP Topic Modeling for Interpretable Clustering of Complex phenotypes

SNPic uses topic modeling to cluster complex phenotypes by interpreting GWAS data as a corpus, identifying interpretable genetic modules and biological mechanisms.

Impact of trait measurement error on quantitative genetic analysis of computer vision derived traits

This study investigates the impact of trait measurement error on quantitative genetic analysis of pig body weight, finding no genetic influence on the error and equivalent heritability between scale-based and image-based measurements.

A fast-to-faithful transition shapes the DNA repair landscape during embryogenesis

The paper investigates DNA repair dynamics during zebrafish embryogenesis, revealing a transition from fast but error-prone repair to slower, more accurate repair mechanisms.

The impact of non-cardiomyocyte MYBPC3 expression on the development of hypertrophic cardiomyopathy

This study investigates the role of MYBPC3 expression in non-cardiomyocytes in HCM development, finding that cardiomyocytes are the primary source of extracardiac MYBPC3 mRNA and the main cell type responsible for the disease.

Genetic Characterization of the TAPBP and Its Haplotypic Association with BF2 in the Chicken Major Histocompatibility Complex

The paper characterizes TAPBP alleles in Korean Native Chickens, identifies novel variants, and explores haplotypic associations with BF2.

Excessive Postnatal Smooth Muscle Differentiation in a Lung Specific Model of TBX4-related Pulmonary Hypertension

This study develops a mouse model of TBX4-related pulmonary hypertension and shows excessive postnatal smooth muscle differentiation in multiple lung compartments.

Linked origins but distinct roles for extreme length and sequence variation at a tandem repeat in CACNA1C

The paper examines a tandem repeat in CACNA1C, showing distinct roles of length and sequence variation in disease risk and gene expression.

Systematic disruption of zebrafish fibrillin genes identifies a translational zebrafish model for Marfan syndrome

This paper creates a zebrafish model of Marfan syndrome by disrupting fibrillin genes, finding that fbn2b-/- zebrafish exhibit cardiovascular phenotypes similar to human disease.

Regulatory network topology and the genetic architecture of gene expression

The paper investigates how gene regulatory network topology influences the genetic architecture of gene expression, finding that local motifs and hub regulators shape heritability distribution.

Genetic parameters and sex-specific architecture of observed and latent fertility phenotypes in a closed breeding nucleus of an Arctic salmonid

The paper estimates genetic parameters and sex-specific architecture of fertility traits in Arctic charr, identifying genetic correlations and trade-offs affecting reproductive success.