Two types of response inhibition failures in humans
The paper identifies a distinct type of response inhibition failure, termed trigger failure, using computational modeling and neural data analysis in humans.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
The paper identifies a distinct type of response inhibition failure, termed trigger failure, using computational modeling and neural data analysis in humans.
Madeleine N. Goldberg, Ava Reck, Amalia M. Skyberg…·Jennifer H. Pfeifer
This study examines age and pubertal changes in social motivation and hippocampal-cortical development in adolescent girls, finding linear and non-linear trends in social goals and structural brain changes.
Silvia Zampar, Y. Mei, Filsy Samuel…·Martin Ingelsson
This study compares soluble α-synuclein species from MSA and LBD brains, finding differences in their seeding activity and size distribution.
Christian Limberger, Guilherme Garcia Schu, Giordana Salvi de Souza…·Eduardo Rigon Zimmer
The paper identifies hyperconnected metabolic networks in preclinical Alzheimer's converters using FDG-PET data, showing network reorganization precedes clinical conversion.
Xiaochen Liu, Xiaoqing Alice Zhou, David Hike…·Xin Yu
The paper analyzes vasomotor rhythms in awake mice using fMRI to show their multiscale propagation patterns across the cortex.
Nils Briel, Viktoria Ruf, Paul Feyen…·Jochen Wolfgang Herms
This paper identifies molecular progression trajectories in PSP by integrating snATACseq and snRNAseq data with tau pathology, revealing cell-type-specific transcriptional changes and glial reactivity.
Alexander Weuthen, Sidhant Chopra, Dario Lucas Helbing…·Martin Walter
This study identifies grey matter coupling patterns with cholinergic nuclei Ch1-4 and their synaptic targets using neuroimaging, showing their correlation with cholinergic markers and potential as disease markers.
S Subbulakshmi, Jennifer Park, Julia E Rathmann-Bloch…·Anthony D. Wagner
This study identifies structural and molecular pathways affecting sustained attention in older adults, showing independent contributions of white matter integrity and preclinical Alzheimer's disease markers.
Lupita Rios, You‐Hsin Lin, Laura Yuan…·Steven J. Shabel
This study identifies GPR151 as a habenula-specific GPCR that modulates behavioral responses to inflammation, with potential therapeutic implications for inflammation-associated depression.
Camille Gontier, Laura Drouvé, Johannes Striebel…·Christian Liemersdorf
The paper develops computational models to simulate how altered gravity affects neuronal activity, showing that microgravity increases firing rates and hypergravity decreases them through modified channel dynamics and mechano-gated channels.
Chien-Hsien Lai, Kyung Ah Park, Pan Xu…·Jianyang Du
The paper identifies distinct functional roles of mPFC-BLA and mPFC-NAc pathways in representing anxiety-like and positive valenced behavioral states through neural activity patterns.
Charlotte F. Brzozowski, Zoe N. Fokakis, Marissa A. Menard…·Laura A. Volpicelli‐Daley
This study shows that α-synuclein aggregates in corticostriatal terminals impair glutamatergic transmission without causing neurodegeneration.
Shelby A. Payne, Haley R Anderson, Isaac M. Brown…·Hainan Lang
This study identifies the auditory nerve glial transition zone as a critical site of age-related immune and glial dysfunction contributing to hearing loss.
Priya Rajagopalan, Gaon Sandy Kim, L. Nate Overholtzer…·Katherine E. Lawrence
This paper identifies widespread gray and white matter volume differences in autism using a large voxel-based morphometry analysis of 3,051 participants.
Nicholas B Rozema, Nicole Zarate, Rachel H. Mansky…·Rocío Gómez‐Pastor
This study identifies HSF1's role in regulating thalamostriatal synapses and cognitive flexibility by controlling transcriptional programs and actin dynamics.
Giuseppina De Rocco, Andrea de Donato, Marzia Tina Indrigo…·Nicoletta Landsberger
This study evaluates the effects of early AMPA receptor potentiation in Rett syndrome models, finding that early treatment improves survival, motor function, and cognition, while later treatment is less effective.
Mohamed Kotb Selim, Daniel Panadero Soler, Silvia De Santis…·Santiago Canals
This paper integrates longitudinal neuroimaging and microbiota data in rats to identify Akkermansia as a microbial modulator of alcohol-induced gut-liver-brain pathology and validates its therapeutic potential.
Jiaming Cao, Yujie Zhao, Jianing Yu
The paper investigates the role of dorsolateral striatum (DLS) in movement initiation and execution using optogenetic inhibition in rats, finding continuous contributions to forelimb and whole-body movements.
Piermatteo Morucci, Mamady Nabé, Sebastian Sauppe…·Anne‐Lise Giraud
The paper investigates hierarchical syntactic planning in speech production using SEEG recordings, finding that core syntactic categories are planned before modifiers and that the hippocampus contributes to sentence structure building.