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This study shows that reduced DNASE1L3 activity in obesity leads to increased cfDNA and inflammation, contributing to metabolic syndrome and MASLD, and that restoring DNASE1L3 can mitigate these effects.

This study investigates the role of AIL7, an AP2/ERF transcription factor, in Arabidopsis immunity against clubroot pathogen, finding it enhances resistance through phytohormone-mediated defense mechanisms.

This study uses a mouse model to show that rapid podocyte ablation leads to acute renal tubule cell necrosis, interstitial fibrosis, and renal failure.

This study identifies pericyte loss preceding endothelial activation in cerebral small vessel disease through single-vessel analysis of human brain tissue.

ViFIT-assisted histopathology converts diverse H&E-stained images into standardized H&E images and generates virtual fiber images, improving diagnostic workflows across cancer types.

This study identifies survivin as a mechanosensitive regulator linking ECM stiffness to GBM growth and matrisome remodeling, suggesting it as a therapeutic target.

This paper evaluates PF-543, a SphK1 inhibitor, against Leishmania donovani, showing reduced parasite load and enhanced immune response both in vitro and in vivo.

This study functionally classifies HCN1 variants in patients with neurodevelopmental disorders, finding genotype-phenotype correlations and potential therapeutic targets.

This paper develops a DINO-DETR model trained on spatial transcriptomics data to detect vascular niches in H&E slides, showing improved vascular quantification and prognostic value in astrocytoma.

This study shows that macrophage extracellular traps (METs) contribute to heart failure by promoting cardiac remodelling through PAD4-dependent mechanisms, and targeting METs may offer therapeutic potential.

This study analyzes gliosarcoma using digital spatial transcriptomics to compare glial and mesenchymal components with glioblastoma, identifying genetic and transcriptomic differences.

This study assesses the prevalence and risk factors of bovine fasciolosis in Bahir Dar, Ethiopia, finding a 49.21% prevalence rate with significant regional and body condition disparities.

This study shows that VEGF-C treatment promotes cardiac lymphangiogenesis, reduces inflammation, and preserves heart function in autoimmune myocarditis in mice.

This study shows that inducible PKA activation in osteoblasts leads to high bone turnover and disease-like phenotypes in mice.

The paper detects H5N1 avian influenza in ratites and identifies mammalian-relevant mutations, suggesting potential zoonotic risk.

This study identifies the LEP-LEPR-CD31 signaling pathway's role in subchondral H-type vessel formation and its contribution to articular cartilage degeneration in osteoarthritis.

This study identifies myeloid HIF-1 as a driver of pulmonary fibrosis by sustaining hypoxic fronts and promoting fibroblast activation and matrix remodeling.

This study develops an immunocompetent mouse model of virus-induced liver fibrosis and hepatocellular carcinoma using Norway rat hepacivirus.

This study shows that botulinum toxin injection in masticatory muscles of rats causes hypertrophic bone proliferation at enthesis through chondrocyte proliferation, not inflammation.

This study shows that Pml loss worsens NEK1-linked ALS, while Pml induction reduces disease symptoms by clearing Nek1t aggregates.