Discover, rate, and verify biology preprints.

Phosphate-responsive ornithine lipid biosynthesis remodels outer membrane composition and contributes to polymyxin tolerance

This study identifies OlsF-dependent ornithine lipid biosynthesis as a phosphate-responsive pathway that remodels the outer membrane and enhances polymyxin tolerance in Enterobacterales.

Heat-evolved strains of the coral symbiont Cladocopium proliferum have diverged in exon usage

The paper analyzes exon usage and alternative splicing in heat-evolved strains of the coral symbiont Cladocopium proliferum to identify genetic differences associated with increased thermal tolerance.

Peptorama: Structure creation and exploratory data analysis for non-ribosomal peptides

Peptorama provides tools for creating and analyzing non-ribosomal peptide structures, enabling efficient comparison of known and predicted peptides to aid in biodiscovery.

Fragment Covalent Bond Formation at SOS1 Tyr-884 Inhibits KRAS Nucleotide Exchange

This paper identifies a covalent inhibitor of SOS1-KRAS binding by screening fragments that form bonds at Tyr-884, showing time- and concentration-dependent inhibition of KRAS nucleotide exchange.

Pervasive chromothripsis drives pleural mesothelioma to impact gene function and patient survival

This study identifies chromothripsis as a common driver of pleural mesothelioma, linked to gene deletions and poor patient survival.

Paired-probe chemoproteomic strategy enables global site-resolved quantification of lysine redox states

The paper introduces PRISM-Lys, a chemoproteomic method to quantitatively map lysine redox states, revealing site-specific changes during ferroptosis.

Multiparametric Extracellular Vesicle Profiling Identifies a Distinct Circulating Signature of Bicuspid Aortic Valve Disease

This study identifies a distinct circulating extracellular vesicle signature in bicuspid aortic valve disease through single-vesicle analysis and proteomic profiling.

Single-cell geometry of drug responses across malignant glioma states

The paper analyzes drug response direction across glioma states using single-cell RNA-seq data, finding that response direction is consistent across states but magnitude varies.

Single-probe, high-yield spatial mapping of diverse short RNA motifs

The paper introduces SMOOTHY-FISH, a method to visualize short RNA motifs at single-molecule resolution, revealing new spatial RNA biology insights in single cells and mouse brain tissues.

A chromosome-level genome assembly of an endangered large carnivore, the wolverine, Gulo gulo gulo (Linnaeus, 1758)

This paper presents a chromosome-level genome assembly for the wolverine, providing a more complete and sex chromosome-inclusive reference for conservation studies.

A Global Atlas of Immune Alleles Reveals Health-Relevant Variation Across Groups

The paper presents GAIA, a global atlas of immune alleles, showing that underrepresented groups have more diverse alleles needed for vaccine design than Northwest European groups.

Connectome structure constrains neural activity across scales

The paper shows that coarse-grained connectome partitions can preserve functional predictions about neural activity even when path structure is lost.

A transient pulse of neuronal ATF4 installs a durable non-autonomous programme promoting healthy ageing

This study shows that transient ATF4 activation in neurons during early adulthood extends healthspan and promotes systemic adaptations in Drosophila.

Segmented regression to streamline semi-mechanistic pharmacodynamic modelling of antibiotic effects

This paper introduces a three-step workflow using segmented regression to improve semi-mechanistic pharmacodynamic modeling of antibiotic effects, demonstrating it with colistin against Pseudomonas aeruginosa.

Functional analysis of small-molecule and protein binding domains using monomeric streptavidin-based two-component biosensors

The paper develops a biosensor platform using monomeric streptavidin to evaluate binding domains for small molecules and proteins, demonstrating ligand-dependent activation with biotinylated targets.

LRCP: identifying functionally related SNPs and genes from phenome-wide genetic-effect correlations using GWAS summary statistics

LRCP identifies functionally related SNPs and genes by estimating phenome-wide genetic-effect correlations from GWAS summary statistics, improving accuracy over naive methods.

Evolutionary and acclimatory shifts in ion transporter gene expression across salinity transitions in the copepod Eurytemora carolleeae

This study examines evolutionary and acclimatory shifts in gene expression of ion transporters in Eurytemora carolleeae across salinity transitions using quantitative PCR.

Sex-specific bone marrow populations regulate skeletal phenotype and identify CD74-marked osteoclast precursor subsets

The paper identifies sex-specific bone marrow cell populations that regulate bone mass and shows CD74 marks osteoclast precursor subsets.

Podoplanin shapes epidermal morphogenesis and coordinates stem cell and epidermal-dermal responses during inflammatory remodelling

This study identifies podoplanin's role in maintaining epidermal organisation and coordinating stem cell and dermal responses during inflammatory skin remodelling.

Rho: A Purpose-Driven Workspace for Human-AI Collaborative Analysis

Rho is a collaborative analysis environment that organizes materials by scientific purpose to support human-AI judgment in bioinformatics.