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Cortical bursts provide spatio-temporal frames for the large-scale phase synchrony emerging across the birth transition

The paper examines how cortical bursts influence phase synchrony development in preterm infants and links persistent phase-based connectivity to poorer neurocognitive outcomes.

Tissue geometry patterns epidermal stem cell fate in murine interfollicular skin

The paper shows that dermal-epidermal junction geometry influences stem cell fate in mouse skin, with concave areas promoting proliferation and convex areas promoting differentiation.

Functional Reconstitution of Human OATP1B1 and OATP1B3 in Proteoliposomes: Effect of Bicarbonate Gradients and Substrate-specific Stimulation on Transport

This study reconstitutes OATP1B1 and OATP1B3 in proteoliposomes to show bicarbonate gradients drive substrate uptake, with EGCG enhancing OATP1B3 transport.

GNG2-MRAS interaction regulates SHOC2-dependent RAF activation and MAPK signaling

This study identifies GNG2 as an inhibitor of the SMP complex by binding MRAS, disrupting its assembly and inhibiting MAPK signaling.

ADRA2B genetic polymorphism modulates vagus nerve stimulation response

This study investigates how a genetic polymorphism in ADRA2B affects responses to vagus nerve stimulation, finding it influences pupillary responses and cortical activity alignment with noradrenergic projections.

Standard touchscreen test procedures shift circadian rhythms in mice: a modified protocol to minimize circadian confounds

This study shows that standard touchscreen testing in mice shifts circadian rhythms and proposes a modified protocol to reduce these effects without affecting cognitive performance.

Imipramine binds to amyloid-β and extends the survival of Alzheimer's disease patients

This study shows imipramine binds to amyloid-β, reduces Aβ accumulation, and improves survival in Alzheimer's patients.

Single-cell characterization of 3D CLL spheroid model that recapitulates lymph node microenvironment-driven phenotypes and in vivo drug responses to ibrutinib

The paper uses a 3D CLL spheroid model to study how lymph node microenvironmental signals influence CLL cell phenotypes and drug responses to ibrutinib.

Brain-wide representations of olfactory behavior in C. elegans

The paper analyzes brain-wide neural activity in C. elegans during olfactory navigation and identifies functional circuits linking sensory input to motor behavior across different environments and behavioral states.

Concrete waste as a source of calcium and alkalinity for coccolithophore cultivation: an experimental test of carbon dioxide removal and sequestration

This study tests using concrete waste to supply calcium and alkalinity for coccolithophore cultivation, showing increased calcite production and CO2 removal potential.

CTLA-4 checkpoint signalling modulates germinal centre dynamics and antibody avidity during Borrelia burgdorferi infection in mice.

This study shows that CTLA-4 signaling impairs antibody quality during Borrelia infection by affecting germinal center dynamics and T cell responses in mice.

FedEpitope: Parameter-Efficient Federated Protein Language Models for Linear B-Cell Epitope Prediction

FedEpitope uses federated learning with LoRA to predict linear B-cell epitopes without centralizing data, achieving good performance across multiple clients.

Combined elevated temperature and CO2 alter Wolbachia abundance and host fitness but not cytoplasmic incompatibility in a stored-product pest

This study examines how elevated temperature and CO2 affect Wolbachia abundance and host fitness in a stored-product pest, finding stable cytoplasmic incompatibility despite changes in Wolbachia dynamics.

A mouse model of metastasis-induced breast cancer cachexia with non-cachectic controls bearing isogenic primary tumors

This paper develops a mouse model of metastasis-induced breast cancer cachexia and identifies that anorexia drives tissue wasting while muscle weakness is independent of food intake.

Chronic hypertension disrupts the blood-brain barrier in the ventral hippocampus in females but not males in a rat model of vascular cognitive impairment

This study shows chronic hypertension increases BBB permeability and anxiety-like behaviors in female rats but not males in a vascular cognitive impairment model.

A Whole-Mouse-Brain Model of Coupled Neural Masses: Analysis of Network Dynamics

The paper analyzes the dynamics of a whole-mouse-brain neural mass model coupled via an empirical connectome, finding chaotic oscillations and suppression of chaos with network modifications.

Reconstitution of lipid nanoparticle-mediated siRNA transfer across endosomal membrane mimics

This study reconstitutes lipid nanoparticle-mediated siRNA transfer across endosomal membranes using GUVs, showing siRNA can translocate without membrane rupture or pH gradient loss.

Comparison of Hydroponic and Substrate-Based Methods for Screening Pea Genotypes for Resistance to Fusarium oxysporum.

This study compares hydroponic and substrate-based methods for evaluating pea genotype resistance to Fusarium oxysporum, finding hydroponics more sensitive in distinguishing susceptible genotypes.

A phase decoder for reconstructing missing muscle activity

This paper introduces a phase decoder that reconstructs missing muscle activity from sparse EMG signals, achieving accurate phase estimation and muscle activation reconstruction in real-time.

Brain mitovesicles undergo stage-specific remodelling during the progression of amyloid-β pathology

This study shows that mitovesicles from Alzheimer's disease mouse models undergo stage-specific proteomic changes that reflect mitochondrial dysfunction and provide a conserved disease signature in humans.