B. Xu

This paper develops an oncolytic viral vector-based vaccine that prevents COVID-19 and treats tumor progression in preclinical models.

This paper applies a dynamical systems framework to transcriptomic data from hematopoiesis, identifying bifurcations in neutrophil differentiation and uncovering key gene contributors.

This study investigates the interaction between the apricot bud gall mite and its host, revealing hormonal changes that drive gall development and providing insights for pest management.

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

This study identifies pseudopollen-like trichomes in Cypripedium wardii that serve both as rewards and deceptive signals to attract pollinators, enhancing reproductive success while causing inbreeding depression.

This paper uses Maxent modeling to predict the global distribution of talaromycosis, identifying key environmental and epidemiological drivers.

This study shows phosphopeptide nanofibers enable caveolae-mediated endocytosis and endosomal escape via TNAP clustering in lipid rafts.

This paper develops a low-cost underwater camera trap network with deep learning for analyzing marine life, showing accurate fish detection and long-term deployment capabilities.

The paper introduces thiophosphopeptides that target the Golgi apparatus and selectively kill cancer cells through enzymatic self-assembly.

This study investigates a fermented Yi traditional medicine, JB10, showing significant in vitro suppression of SARS-CoV-2 replication with EC50 of 769.1 dilutions and a selection index of 42.68.

The paper shows DNA demethylation of Foxp3 enhancer CNS2 switches transcriptional drivers to maintain Treg identity by stabilizing Foxp3 expression.

This study identifies rosmarinic acid as a potent inhibitor of amylin aggregation and shows its efficacy in reducing amyloid deposits and mitigating diabetic pathology in HIP rats.

This study examines the microbiome of ground beetles across different diets and finds that soil environment, not diet, significantly affects bacterial diversity and composition.

The paper identifies catechol-containing compounds as broad amyloid inhibitors and shows redox state determines their activity.

This study investigates the physical principles of two-component biomolecular phase separation using simulations and theory, revealing a magic-ratio effect that suppresses phase separation at specific stoichiometries.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This study shows KDM6B promotes oncogenic CDK4/6-pRB-E2F pathway activation in neuroblastoma by maintaining enhancer activity, and its inhibition correlates with poor patient survival.

This paper performs population pharmacokinetics analysis of camrelizumab and finds no significant advantage of flat-dose or weight-based dosing regimens.

This study investigates ion and water permeation mechanisms of the SARS-CoV-2 E protein channel using in silico methods, revealing hydrophobic gates and voltage-dependent behavior.

The paper uses a HOXA9-mCherry reporter and CRISPR/Cas9 screens to identify USF1/USF2 as regulators of HOXA9 in MLLr leukemia, showing their role in leukemia cell proliferation.

This study shows that lung-stage schistosome infection reduces allergic airway inflammation by increasing allergen-specific Treg cells that inhibit IgE and Th2 cytokine production.

The paper develops interpretable deep learning models to search for similar disease states across social media and PubMed using histopathology images and clinical data, achieving high precision in real-time diagnosis assistance.

This study identifies circ_0005962 as an oncogene in NSCLC that promotes progression via the circ_0005962/miR-382-5p/PDK4 regulatory network.

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

This study investigates human tau isoform aggregation in Alzheimer's disease, showing 3R tau aggregates faster than 4R and identifies key domains for aggregation, while demonstrating the use of RT-QuIC to detect misfolded tau.

This study identifies GABA as an endogenous plant signal that regulates stomatal movement and drought tolerance by inhibiting anion transporters in guard cells.

The paper shows that Dscam isoforms in Chelicerata form cis-multimers and trans-self-bind via Ig1 domains to generate unique homophilic recognition specificities for neuronal self-avoidance.

This paper derives general forms of fluorescence correlation spectroscopy (FCS) and photon counting histogram (PCH) for bounded systems, enabling accurate quantification of molecular kinetics in finite domains.

This study shows BMP9 induces osteogenic differentiation in GC-1spg cells through upregulated markers and in vivo bone formation.

This paper presents a 3D printed microheater integrated microneedle patch system for controlled drug delivery, demonstrating its integration with wearable electronics for pain management.