B. Zhang

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

This study identifies aglycone polyether ionophores as broad-spectrum antivirals effective against multiple enveloped viruses, including SARS-CoV-2, and demonstrates their efficacy in curing JEV-infected mice.

The paper introduces Deep-LUMEN, a deep learning algorithm for classifying lung epithelial spheroids from brightfield images, and validates its ability to detect morphological changes in response to drug treatments.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

This paper uses cryo-EM to show how SARS-CoV-2 spike protein undergoes pH-dependent structural changes that affect ACE2 binding and antibody evasion.

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

The paper examines age-dependent glycomic responses to the 2009 H1N1 influenza virus and links these responses to disease severity in a ferret model.

This study evaluates how bead-beating intensity affects DNA extraction from mouse and human stool, finding that 4 minutes of beating optimizes microbiome recovery for most taxa.

The paper develops a mathematical framework to analyze epigenetic stability using stochastic reaction networks and applies it to a chromatin state model to identify bistability and transition paths.

This paper develops a nanoparticle platform for displaying trimeric antigens, showing that SARS-CoV-2 spike-LuS nanoparticles induce 25-fold higher neutralizing responses than spike alone.

This study evaluates the therapeutic effects of IL12IL2GMCSF fusion protein in canine tumors, showing significant response rates with minimal adverse effects.

The paper investigates how SARS-CoV-2 infection induces epithelial-mesenchymal transition (EMT) in lung cancer models, leading to changes in gene expression and potential therapeutic targets.

This study shows that blocking CTLA-4 reverses Treg cell suppression of anti-TB T-cell responses in tuberculosis patients.

This paper identifies N-glycosylation as essential for Phytophthora sojae growth and pathogenicity, revealing two distinct N-glycosylation motifs and their functional roles in key life stages.

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.

This study identifies high mannose as a key mediator of influenza severity through glycomic analysis in a ferret model.

The paper identifies a new acetate and ATP synthesis pathway in bacteria, showing it is widespread across multiple species and phyla.

This paper shows that co-activation of NF-κB and MYC in cancer cells makes them dependent on IL6 for survival and leads to a poorly-differentiated state similar to human plasmablastic lymphoma and t(8;14)[MYC-IGH] multiple myeloma.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

This study uses simulations to show how transcription affects nucleosome positioning differently in yeast and mouse, revealing enzyme competition and polymerase effects.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

This study identifies GRASLND as a primate-specific lncRNA that enhances chondrogenesis by suppressing interferon type II signaling in mesenchymal stem cells.

This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.