B. Zhang

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This study shows that USP21 knockout in Treg cells disrupts immune regulation during Schistosoma japonicum infection, promoting parasite survival and altering immune responses while reducing immune pathology.

The paper introduces a data-driven polymer model to study diploid genome organization, validated against Hi-C data and showing chromosome positioning principles.

This study uses a CRISPR screen in mouse Tregs to identify genes regulating Foxp3 expression, finding Usp22 and Atxn7l3 as stabilizers and Rnf20 as a destabilizer.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.

This study evaluates drug inhibitory effects on Babesia parasite growth using real-time PCR with 18S rRNA quantification and shows significant gene expression reduction after drug treatment.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.

The paper identifies P5CS as a CTPS-interacting protein in Drosophila and shows they form cytoophidia, linking two enzymes in pyrimidine and proline biosynthesis.

The paper applies TurboID-mediated biotinylation to characterize the cytoophidium proteome in Drosophila, demonstrating its utility for studying subcellular compartments.

This paper identifies aCPSF1 as the first general transcription termination factor in Archaea, revealing its cleavage-dependent termination mechanism and evolutionary relationship to eukaryotic processes.

The paper uses a variational autoencoder to analyze chromatin structure fluctuations and identifies a reaction coordinate for chromatin folding, revealing insights into TAD formation and folding energetics.

The paper develops a luciferase-based murine model and cell assay to evaluate the efficacy of MetRS inhibitor 1717 against Giardia lamblia, showing its potent in vivo activity.

This study develops microscaled proteogenomic methods for cancer analysis, showing treatment response and resistance mechanisms in ERBB2-positive breast cancers.

This study investigates how PRC2 interacts with chromatin using single-molecule force spectroscopy and simulations, revealing new binding configurations and their regulation.

This study shows that IL-22 and IL-18 prevent and cure rotavirus infection by distinct mechanisms involving cell extrusion and pyroptosis in intestinal epithelial cells.

The paper identifies CREBBP dependency in a DLBCL cell line with EP300 truncation using CRISPR-Cas9 screens and genomic data, suggesting therapeutic targets for heterogeneous cancers.

This study uses single-cell RNA sequencing to analyze viral transcription and host responses in influenza-infected cells, revealing cell-to-cell variation driven by defective viral genomes.

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.

The paper engineers a polymerase to monitor electrical activity by adding biotinylatable contacts, showing enhanced current fluctuations when activated.

The paper develops a theoretical framework to model nucleosome positioning by approximating ATP-driven remodeling enzymes with effective equilibrium models, validated through simulations.

This paper describes a resource of pediatric high grade glioma (pHGG) data and biospecimens from the CBTTC and PBTA, including genomic, clinical, and imaging data, along with cell lines and tissue microarrays.

This study fabricates Ag-doped SnO2 hollow nanofibers and demonstrates that silver doping enhances their antibacterial activity compared to pure SnO2.

This study identifies O-GlcNAc transferase as a suppressor of hepatocyte necroptosis and liver fibrosis, using both human and mouse models.