C. Liu

This study identifies pyruvate as an inhibitor of cPLA2 that reduces obesity and inflammation in mice by targeting this enzyme, suggesting its potential as a therapeutic agent.

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

A computational model predicts influenza virus evolution and aids in vaccine strain selection by modeling site-wise mutation dynamics.

This study shows that pectin methylesterase activity is necessary for RALF1 peptide signaling, as it enables binding to de-methylesterified pectin for FERONIA-dependent perception.

This paper introduces GSE-Seq, a high-throughput platform for single-entity sequencing that enables long-read profiling of dsDNA and ssDNA from viruses and bacteria, revealing previously overlooked dark matter and phage-host interactions.

The paper measures interfacial tension in epithelial tissues and shows how it contributes to delamination from substrates, revealing mechanical stability mechanisms.

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

This study identifies essential genes and genomic features of Xanthomonas citri using transposon mutagenesis, revealing insights into its genome organization and potential therapeutic targets.

This study identifies T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort using mass cytometry and random forest analysis.

This study identifies conserved M protein peptides that elicit cross-neutralizing antibodies against multiple SARS-CoV-2 variants, including Omicron, when combined with RBD-specific antibodies.

The paper introduces a Proxitome-RNA-capture method to study RNA composition in Arabidopsis processing bodies, revealing dynamic RNA regulation and its role in stress responses.

This study tracks GAF's chromatin search mechanism using smFRET and imaging, showing 1D-3D diffusion enables efficient target finding despite nucleosome barriers.

This study examines how foot placement control strategies during unperturbed walking generalize to perturbed gait, finding poor generalization and differential sensitivity to forward and backward perturbations.

This study compares the effects of homologous mutations in three muscle myosin isoforms, finding divergent molecular impacts that correlate with disease severity.

This study shows that phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures with different neurotoxicity and propagation properties.

The paper analyzes genomic, metabolic, and ecological data from nearly all Saccharomycotina yeast species to show that intrinsic genetic factors, not trade-offs or extrinsic factors, drive variation in niche breadth.

This study presents a reference genome for industrial chicory and identifies key genes and molecular processes in anther development and male sterility using transcriptomic and morphological analyses.

This paper presents the structural study of the interaction between ESV1 and LESV from Arabidopsis thaliana, showing LESV intervenes during amylopectin biosynthesis.

This study tracks human neural progenitor cell grafts in adult rats up to 9 months, revealing their migration and differentiation patterns, and highlights their potential for neural repair.

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

This study shows metformin improves bone healing in diabetic mice by enhancing BMSC differentiation and chondrogenesis.

Cflows infers continuous cell state transitions and gene regulatory networks from static scRNA-seq data, revealing ESRRA as a key driver of tumor formation.

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

This study shows ANKRD49 promotes metastasis in NSCLC cells by activating the JNK-ATF2/c-Jun-MMP-2/9 pathway.

The paper proposes a lightweight fine-tuning method for pretrained protein language models to improve secondary structure prediction performance.

The paper identifies metacaspases as regulators of seed longevity by modulating CDC48 activity through proteolytic control of its adaptor PUX.

This study identifies a unique CD8+ T cell population in AD mouse brains that contributes to amyloid beta-associated memory loss and shows that reducing these cells improves memory and reduces plaque formation.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

This paper develops a vascularized bile duct-on-a-chip model to study PSC, showing PSC cholangiocytes exhibit increased inflammation under IL-17A stimulation.