H. Chen

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

The paper identifies CX3CR1 expression on circulating CD8+ T cells as a biomarker predicting response to immune checkpoint inhibitor therapy in NSCLC patients.

This study uses single-cell transcriptomics and protein profiling to analyze EBOV infection in rhesus monkeys, revealing changes in immune cell dynamics and viral/host gene expression.

This study examines the susceptibility of various animals to SARS-CoV-2, finding efficient replication in ferrets and cats but not in dogs, pigs, chickens, or ducks.

This study shows that seminal plasma exosomes increase human sperm calcium levels via the CatSper channel, improving motility and offering potential clinical applications for asthenozoospermia.

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

This study identifies METTL5 as an 18S rRNA-specific m6A methyltransferase that modulates stress response gene expression by affecting translation.

The paper investigates how vegetation and microbes interact to preserve organic matter in wooded peatlands, finding that slow-growing microbes and plant-induced recalcitrant carbon reduce carbon loss despite climate stressors.

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

The paper uses computational simulations to study the binding dynamics between human ACE2 and the SARS-CoV-2 spike protein's RBD, revealing critical residues and binding modes.

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

This study shows that LZTR1 inactivation in glioblastoma stabilizes RIT1, leading to MAPK/ERK pathway activation and promoting tumor growth.

This paper introduces a NIR-II cell tracker for real-time monitoring of stem cell behavior in vivo, revealing differential responses to diseased environments and enabling long-term tracking beyond 30 days.

This paper analyzes ancient Y chromosome data to support the Asia origin model for modern human paternal lineages over the African origin model.

This paper introduces an amorphous nickel-titanium alloy film as a new supporting substrate for cryoEM, showing improved electron conductivity and reduced beam-induced motion, leading to better particle distribution and resolution.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

This study identifies BCAT2 as a suppressor of ferroptosis in cancer cells, showing its role in regulating glutamate levels and enhancing resistance to ferroptosis-inducing therapies.

This study shows that rats emit distinct volatile organic compound profiles in their breath when exposed to various airborne toxicants, indicating a potential for using breath analysis to monitor air toxicity.

The paper shows MEcPP coordinates auxin and ethylene signaling via phytochrome B to regulate hypocotyl growth in response to light.

This paper identifies centromeres in Phytophthora sojae using long-read sequencing and ChIP-seq, revealing transposon-rich, heterochromatic regions distinct from other SAR supergroup organisms.

This study shows that eating breakfast instead of an evening snack increases lipid oxidation in older adults, highlighting the impact of meal timing on metabolism.

This study uses single-cell RNA sequencing to characterize mouse epididymal cell types and their gene expression profiles, identifying seven known and two novel cell populations along with region-specific gene expression signatures.

The paper introduces a length penalized probabilistic principal curve algorithm and applies it to handwritten digits and pharmacologic colon imaging to improve curve modeling.

The paper shows that gut bacteria use reductive amino acid metabolism to produce metabolites that circulate in the host, linked to energy capture via the Rnf complex.

This study develops an anti-somatostatin receptor 2 antibody-drug conjugate (ADC) that effectively targets and kills neuroendocrine tumors with minimal toxicity.

This study applies r- and K-selection to HeLa cells to show how life history strategies influence tumor functional diversity through gene expression and ecological competition.

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.

The paper shows that phyB induces alternative splicing of PIF3, leading to intron retention in the 5UTR and uORF-mediated translational inhibition, regulated by the short-day diurnal cycle.

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.