H. Lee

The paper demonstrates that antibiotic-resistant cells can be inhibited by exploiting fitness trade-offs using norvaline to target genetic mutations in leucyl-tRNA synthetase in tavaborole-resistant E. coli.

This study finds that patients with heart failure have a higher risk of developing cancer compared to the general population, with increased risk observed across multiple cancer types.

This study uses linked-read sequencing to track genetic and ecological changes in a human gut microbiome during antibiotic treatment and recovery.

This study shows that hepatocytic Prominin-1 prevents liver fibrosis by stabilizing SMAD7, thereby inhibiting TGFβ signaling.

The paper shows that Prom1 regulates hepatic gluconeogenesis by modulating PKA activity through its interaction with radixin.

This study shows LRRK2 is recruited to maturing phagosomes and required for Rab8a and Rab10 recruitment in human macrophages.

This study uses rOMT to analyze glymphatic transport, showing faster solute speed in CSF and regional differences in brain parenchyma, with implications for neurodegenerative diseases.

This study shows that loss of BubR1 acetylation causes replication stress and complex chromosomal rearrangements in tumors.

The paper investigates cerebral metabolism in cancer patients and finds three alert patients with glucose consumption rates typical of deep sleep or anesthesia, suggesting a metabolic shift possibly linked to cancer.

This study analyzes 40 years of canine parvovirus evolution, finding limited intra-host diversity and slow genetic change despite its adaptability.

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

The paper shows that base-pair substitution rates in E. coli vary symmetrically across the chromosome due to multiple factors affecting replication and repair.

This study identifies microbiota-dependent gene expression changes in Drosophila melanogaster heads using RNA-seq and nanoString nCounter, revealing genes involved in immune response, metabolism, and stress resistance.

This paper introduces two-photon pharmacology to reversibly silence mGlu5 receptors in intact brain tissue, enabling study of synaptic and signaling processes.

This study identifies the biosynthetic gene cluster for triacsins in Streptomyces aureofaciens and discovers a new producer species.

This paper develops a deep transfer learning method to classify LDIH holograms without image reconstruction, enabling low-cost point-of-care diagnostics.

This study identifies gut bacteria, particularly Clostridiales, as a source of tacrolimus metabolism, producing less potent metabolites that may explain variable drug exposure after oral dosing.

This study uses in silico drug repositioning to identify bortezomib as an inhibitor of GALNT14-driven lung cancer metastasis, validated through in vitro and in vivo experiments.

The paper identifies host genes that regulate Wolbachia levels in Drosophila using genome-wide RNAi screening and FISH assay, revealing that translation components influence Wolbachia abundance.

The paper introduces a high-throughput platform, TrueRepertoire, for accurate clone identification and retrieval in phage display libraries, validated on a human hepatocyte growth factor-targeting scFv library.

This paper shows that Bacillus velezensis K68 inhibits Streptococcus mutans biofilm formation, adhesion, and glucosyltransferase gene expression through 1-deoxynojirimycin production.

This study shows that increasing classroom humidity reduces influenza virus presence and infectivity in preschool settings.