H. Zhao

This study shows that Cep57 and Cep57l1 recruit the Cep63-Cep152 complex to mother centrioles, enabling centriole duplication.

This study traces the evolutionary origin of the Hippo pathway from unicellular ancestors and examines its oncogenic alterations in mammals.

The paper engineers the auroramycin biosynthetic pathway in Streptomyces roseoporous to identify key structural features responsible for its antimicrobial activity.

This study establishes a trans-resveratrol-induced mouse pulmonary fibrosis model and compares it to the bleomycin-induced model, finding it causes less damage and progresses more slowly.

This study shows that an antisense oligonucleotide reduces Hdac2 mRNA and enhances memory in mice by inhibiting RNA polymerase II elongation.

This study shows that combining sirolimus and nintedanib treats vascular abnormalities in HHT mouse models by targeting multiple pathways.

The paper generates a comprehensive Arabidopsis proteome atlas and library, then uses DIA-MS to study abscisic acid effects, identifying differentially expressed proteins.

The paper introduces a presuppositionless method to analyze single nanoparticle trajectories by leveraging their historical data, revealing spatiotemporal patterns without predefined models.

This paper introduces ctASLM, a light-sheet microscopy technique with sub-micron isotropic resolution and large-scale imaging, enabling automated cell and subcellular feature detection in cleared tissues.

This study uses molecular dynamics simulations to analyze the thermodynamic and dynamic properties of canonical and CENP-A histone tetramers, revealing structural differences and their implications for nucleosome assembly.

The paper shows TAp73 and miR449 work together to support multiciliogenesis, with their combined loss causing brain defects and hydrocephalus.

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

The paper shows that mother centrioles are not required for deuterosome formation and function during basal body amplification in multiciliate cells.

This study identifies AtERG2, a mitochondrial GTPase in Arabidopsis, as essential for early embryo development, with mutants showing seed abortion and ROS accumulation.

The paper introduces SHACKTeR, a method for live cell imaging of specific chromosomal regions using CRISPR/Cas9 and TetO repeats, successfully labeling 9 loci in HCT116 cells with up to 20% efficiency.

This study identifies tacrolimus as a drug that activates Smad1/5/8 signaling and reduces vascular pathology in HHT models.

The paper investigates gene expression variations in yeast and finds most are neutral, not adaptive, suggesting random mutations drive expression evolution.

This study uses transmammary delivery of anti-BMP9/10 antibodies to induce HHT-like vascular defects in mouse neonates, revealing consistent retinal pathology and increased angiopoietin-2 expression.