H. Zhao

Biochemical and transgenic analyses reveal that Petunia hybrida S3-RNase cytotoxicity is largely restricted by a stepwise ubiquitination and degradation pathway during cross-pollination.

This study shows that condensins SMC and MksBEF in Pseudomonas aeruginosa are essential for corneal virulence by regulating gene expression programs involved in metabolism, virulence factors, and bacterial lifestyle.

This study compares intranasal and intramuscular delivery of a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine in hamsters, finding that intranasal immunization provides superior protection against infection and inflammation.

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

The paper identifies CH25H and its product 25HC as inhibitors of SARS-CoV-2 replication by blocking membrane fusion.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

This study presents a molecular model of mammalian Mediator complex using cryo-EM, revealing the structure of the previously unresolved Tail module and its interactions with core Mediator.

This study investigates how day length affects flowering time in Miscanthus and sugarcane to enable synchronized hybridization, finding that day length requirements vary by species and geographic origin.

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.

The paper introduces CRSO to identify cooperating driver combinations in cancer, finding 11 core combinations per cancer type with clinical relevance.

This study shows that fecal microbiota transplantation (FMT) restores gut microbiota balance and protects the intestinal barrier in septic mice by enhancing short-chain fatty acid production.

This study investigates the roles of SMC and MksBEF condensins in chromosome organization and segregation in Pseudomonas aeruginosa, revealing their distinct and coordinated dynamics.

This study develops two neutralization assays for SARS-CoV-2 using VSV and a clinical isolate, showing high concordance between monoclonal, polyclonal antibodies, and ACE2-Fc in neutralizing activity.

This study shows androgen signaling increases ACE2 levels, contributing to severe COVID-19 in men, and suggests androgen receptor inhibition as a potential treatment.

The paper introduces a hybrid light-sheet microscope that enables versatile multi-scale imaging of cleared tissues with varying resolution, geometry, and compatibility requirements.

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

The paper identifies stromal genes differentially expressed in lobular breast cancer, highlighting pregnancy-associated-plasma protein-A (PAPPA) as a potential prognostic marker.

This paper develops a multiplexed CRISPR/Cas9 system with Trex2 exonuclease to improve genome editing efficiency in Setaria viridis, achieving high mutation rates and MMEJ-mediated repair.

This study shows that miR-203 suppresses pancreatic cancer cell proliferation, invasion, and migration by down-regulating FGF2 expression.

This paper introduces a dynamic aqueous multiphase reaction system for rapid, sensitive, and quantitative CRISPR-Cas12a-based molecular diagnosis of HPV16/18 DNA.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This study shows ARHGEF3 promotes muscle regeneration and strength by enhancing autophagy, independent of mTORC2-Akt signaling, in both young and aged mice.

The paper develops a robust ChIP protocol that significantly improves enrichment fold in birch and Arabidopsis, and is applicable to both woody and herbaceous plants.

This study investigates LINC00152's role in esophageal adenocarcinoma, finding it promotes tumor progression via STAT3 and c-MYC signaling and suggests it as a biomarker and therapeutic target.

The paper analyzes transcriptomic and proteomic data from a new cytoplasmic male sterile cotton line to identify differentially expressed genes and proteins involved in microspore abortion.

This study shows LRRK2 and Rab10 coordinate macropinocytosis in phagocytes, with LRRK2 phosphorylating Rab10 to block cargo recycling and promote signaling endosome maturation.