H. Zheng

This paper shows that Vitamin C reduces ACE2 protein levels and blocks SARS-CoV-2 infection in cell and mouse models by inhibiting USP50-ACE2 interaction.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

This paper identifies a NOTCH1-SIRT1-KAT7 axis in T-ALL that promotes leukemia and resistance to therapy, suggesting new therapeutic targets.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study identifies Mbnl3 as a placenta-specific X-linked gene that restricts placental growth in eutherians through altered RNA binding specificities and novel biological functions.

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

The paper builds a comprehensive Plant Virus Database (PVD) containing 3,206 virus species and 9,604 host interactions, revealing significant virome differences between plant groups and regions.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

This study shows that ablating proliferating osteoblast lineage cells after fracture in mice leads to atrophic nonunion, providing a new model for studying this condition.

The paper curates an atlas of human viruses, revealing increased diversity in infants and factors influencing tissue tropism, while introducing the Human Virus Database.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This paper develops a pipeline to identify single-copy protein-coding genes for accurately quantifying sequence-discrete populations in microbial communities, validated using Gilliamella in honeybee guts.

This paper develops a hydrogel microneedle assay using aptamer probes for reagentless glucose quantification in interstitial fluid, showing accurate tracking of glucose levels in a diabetic animal model.

This paper develops Ub variant inhibitors for JAMM-family DUBs STAMBP and STAMBPL1, showing high affinity and selectivity, with structural insights and improved potency over existing inhibitors.

The paper reports the cryo-EM structure of the ferrichrome importer FhuCDB from E. coli, revealing unique features and functional insights into iron-chelated siderophore transport.

The paper reports the structure of the YbtPQ importer in the occluded state using cryo-EM, revealing structural rearrangements and dimerization mechanisms.

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

This paper develops a Cas13a-based assay for detecting Neisseria gonorrhoeae and identifying azithromycin resistance mutations, showing high sensitivity and concordance with existing methods.

This study shows that a live attenuated influenza virus vaccine lacking NS1 provides broad protection against respiratory viruses including SARS-CoV-2 by inducing both innate and adaptive immune responses.

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

This study develops a method to sequence nearly full-length rRNA genes from environmental samples, achieving high accuracy and coverage in microbial community analysis.

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

This study identifies BREVIPEDICELLUS and ERECTA pathways that prevent Arabidopsis callus browning by regulating AtPRX17 expression.

This study shows that SETD7 methylates KRAS at lysine 182 and 184, promoting its degradation and suppressing RAS/MEK/ERK signaling, thereby acting as a tumor suppressor in NSCLC.

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

The paper shows that CSP reduces ATG levels via ubiquitination by NEDD4, enabling EEFs to evade IFN-gamma-mediated killing in hepatocytes.

This study shows that PP-IX nanostructures modulate protein aggregation through oxidation and binding, with albumin affecting their cytotoxic effects.